Yang P - Search Results

1

ADAR1 is required for acute myeloid leukemia cell survival by modulating post-transcriptional Wnt signaling through impairing miRNA biogenesis.

Shi Z, Li J, Ding J, Zhang Y, Min W, Zhu Y, Hou Y, Yuan K, Sun C, Wang X, Shen H, Wang L, Liang SQ, Kuang W, Wang X, Yang P. Shi Z, et al. Among authors: yang p. Leukemia. 2024 Dec 19. doi: 10.1038/s41375-024-02500-7. Online ahead of print. Leukemia. 2024. PMID: 39702795

2

Lead discovery, chemical optimization, and biological evaluation studies of novel histone methyltransferase SET7 small-molecule inhibitors.

Hou Z, Min W, Zhang R, Niu A, Li Y, Cao L, Han J, Luo C, Yang P, Ding H. Hou Z, et al. Among authors: yang p. Bioorg Med Chem Lett. 2020 May 1;30(9):127061. doi: 10.1016/j.bmcl.2020.127061. Epub 2020 Feb 25. Bioorg Med Chem Lett. 2020. PMID: 32173197

3

Discovery of novel and selective CDK4/6 inhibitors by pharmacophore and structure-based virtual screening.

Yuan K, Min W, Wang X, Li J, Kuang W, Zhang F, Xie S, Yang P. Yuan K, et al. Among authors: yang p. Future Med Chem. 2020 Jun;12(12):1121-1136. doi: 10.4155/fmc-2020-0011. Epub 2020 May 13. Future Med Chem. 2020. PMID: 32400188

4

Sodium cantharidinate, a novel anti-pancreatic cancer agent that activates functional p53.

Liu X, Zhang L, Thu PM, Min W, Yang P, Li J, Li P, Xu X. Liu X, et al. Among authors: yang p. Sci China Life Sci. 2021 Aug;64(8):1295-1310. doi: 10.1007/s11427-019-1753-3. Epub 2020 Nov 3. Sci China Life Sci. 2021. PMID: 33165811

5

Selective inhibition of CDK4/6: A safe and effective strategy for developing anticancer drugs.

Yuan K, Wang X, Dong H, Min W, Hao H, Yang P. Yuan K, et al. Among authors: yang p. Acta Pharm Sin B. 2021 Jan;11(1):30-54. doi: 10.1016/j.apsb.2020.05.001. Epub 2020 May 23. Acta Pharm Sin B. 2021. PMID: 33532179 Free PMC article. Review.

6

Design, synthesis, and biological evaluation of novel tetrahydroprotoberberine derivatives to reduce SREBPs expression for the treatment of hyperlipidemia.

Ge H, Zhang W, Yuan K, Xue H, Cheng H, Chen W, Xie Y, Zhang J, Xu X, Yang P. Ge H, et al. Among authors: yang p. Eur J Med Chem. 2021 Oct 5;221:113522. doi: 10.1016/j.ejmech.2021.113522. Epub 2021 May 5. Eur J Med Chem. 2021. PMID: 33984804

7

Computational discovery, structural optimization and biological evaluation of novel inhibitors targeting transient receptor potential vanilloid type 3 (TRPV3).

Zhang F, Lin Y, Min W, Hou Y, Yuan K, Wang J, Yang P. Zhang F, et al. Among authors: yang p. Bioorg Chem. 2021 Sep;114:105093. doi: 10.1016/j.bioorg.2021.105093. Epub 2021 Jun 13. Bioorg Chem. 2021. PMID: 34182309

8

Design, Synthesis, and Biological Evaluation of Icaritin Derivatives as Novel Putative DEPTOR Inhibitors for Multiple Myeloma Treatment.

Hou Y, Kuang W, Min W, Liu Z, Zhang F, Yuan K, Wang X, Sun C, Cheng H, Wang L, Xiao Y, Pu S, Xin GZ, Yang P. Hou Y, et al. Among authors: yang p. J Med Chem. 2021 Oct 28;64(20):14942-14954. doi: 10.1021/acs.jmedchem.1c00087. Epub 2021 Oct 13. J Med Chem. 2021. PMID: 34644502

9

Tubeimoside-1 induces TFEB-dependent lysosomal degradation of PD-L1 and promotes antitumor immunity by targeting mTOR.

Liu X, Yin M, Dong J, Mao G, Min W, Kuang Z, Yang P, Liu L, Zhang N, Deng H. Liu X, et al. Among authors: yang p. Acta Pharm Sin B. 2021 Oct;11(10):3134-3149. doi: 10.1016/j.apsb.2021.03.039. Epub 2021 Apr 1. Acta Pharm Sin B. 2021. PMID: 34745852 Free PMC article.

10

Discovery of novel and orally bioavailable CDK 4/6 inhibitors with high kinome selectivity, low toxicity and long-acting stability for the treatment of multiple myeloma.

Yuan K, Kuang W, Chen W, Ji M, Min W, Zhu Y, Hou Y, Wang X, Li J, Wang L, Yang P. Yuan K, et al. Among authors: yang p. Eur J Med Chem. 2022 Jan 15;228:114024. doi: 10.1016/j.ejmech.2021.114024. Epub 2021 Nov 29. Eur J Med Chem. 2022. PMID: 34875521

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