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Cancer mutations rewire the RNA methylation specificity of METTL3-METTL14.
Zhang C, Scott RL, Tunes L, Hsieh MH, Wang P, Kumar A, Khadgi BB, Yang YY, Doxtader Lacy KA, Herrell E, Zhang X, Evers B, Wang Y, Xing C, Zhu H, Nam Y. Zhang C, et al. Among authors: zhu h. Sci Adv. 2024 Dec 20;10(51):eads4750. doi: 10.1126/sciadv.ads4750. Epub 2024 Dec 20. Sci Adv. 2024. PMID: 39705353 Free PMC article.
PKD1 mutant clones within cirrhotic livers inhibit steatohepatitis without promoting cancer.
Zhu M, Wang Y, Lu T, Guo J, Li L, Hsieh MH, Gopal P, Han Y, Fujiwara N, Wallace DP, Yu ASL, Fang X, Ransom C, Verschleisser S, Hsiehchen D, Hoshida Y, Singal AG, Yopp A, Wang T, Zhu H. Zhu M, et al. Among authors: zhu h. Cell Metab. 2024 Aug 6;36(8):1711-1725.e8. doi: 10.1016/j.cmet.2024.05.015. Epub 2024 Jun 19. Cell Metab. 2024. PMID: 38901424
Suppression of the SWI/SNF Component Arid1a Promotes Mammalian Regeneration.
Sun X, Chuang JC, Kanchwala M, Wu L, Celen C, Li L, Liang H, Zhang S, Maples T, Nguyen LH, Wang SC, Signer RA, Sorouri M, Nassour I, Liu X, Xu J, Wu M, Zhao Y, Kuo YC, Wang Z, Xing C, Zhu H. Sun X, et al. Among authors: zhu h. Cell Stem Cell. 2016 Apr 7;18(4):456-66. doi: 10.1016/j.stem.2016.03.001. Epub 2016 Mar 24. Cell Stem Cell. 2016. PMID: 27044474 Free PMC article.
Liver homeostasis is maintained by midlobular zone 2 hepatocytes.
Wei Y, Wang YG, Jia Y, Li L, Yoon J, Zhang S, Wang Z, Zhang Y, Zhu M, Sharma T, Lin YH, Hsieh MH, Albrecht JH, Le PT, Rosen CJ, Wang T, Zhu H. Wei Y, et al. Among authors: zhu h, zhu m. Science. 2021 Feb 26;371(6532):eabb1625. doi: 10.1126/science.abb1625. Science. 2021. PMID: 33632817 Free PMC article.
Positive selection of somatically mutated clones identifies adaptive pathways in metabolic liver disease.
Wang Z, Zhu S, Jia Y, Wang Y, Kubota N, Fujiwara N, Gordillo R, Lewis C, Zhu M, Sharma T, Li L, Zeng Q, Lin YH, Hsieh MH, Gopal P, Wang T, Hoare M, Campbell P, Hoshida Y, Zhu H. Wang Z, et al. Among authors: zhu s, zhu h, zhu m. Cell. 2023 Apr 27;186(9):1968-1984.e20. doi: 10.1016/j.cell.2023.03.014. Epub 2023 Apr 10. Cell. 2023. PMID: 37040760 Free PMC article.
Metabolic inflexibility promotes mitochondrial health during liver regeneration.
Wang X, Menezes CJ, Jia Y, Xiao Y, Venigalla SSK, Cai F, Hsieh MH, Gu W, Du L, Sudderth J, Kim D, Shelton SD, Llamas CB, Lin YH, Zhu M, Merchant S, Bezwada D, Kelekar S, Zacharias LG, Mathews TP, Hoxhaj G, Wynn RM, Tambar UK, DeBerardinis RJ, Zhu H, Mishra P. Wang X, et al. Among authors: zhu h, zhu m. Science. 2024 Jun 14;384(6701):eadj4301. doi: 10.1126/science.adj4301. Epub 2024 Jun 14. Science. 2024. PMID: 38870309 Free PMC article.
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