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The physicochemical properties of lipopolysaccharide chemotypes regulate activation of the contact pathway of blood coagulation.
Lira AL, Taskin B, Puy C, Keshari RS, Silasi R, Pang J, Aslan JE, Shatzel JJ, Lorentz CU, Tucker EI, Schmaier AH, Gailani D, Lupu F, McCarty OJT. Lira AL, et al. Among authors: tucker ei. J Biol Chem. 2024 Dec 18;301(1):108110. doi: 10.1016/j.jbc.2024.108110. Online ahead of print. J Biol Chem. 2024. PMID: 39706265 Free article.
Factor XII Activation Promotes Platelet Consumption in the Presence of Bacterial-Type Long-Chain Polyphosphate In Vitro and In Vivo.
Zilberman-Rudenko J, Reitsma SE, Puy C, Rigg RA, Smith SA, Tucker EI, Silasi R, Merkulova A, McCrae KR, Maas C, Urbanus RT, Gailani D, Morrissey JH, Gruber A, Lupu F, Schmaier AH, McCarty OJT. Zilberman-Rudenko J, et al. Among authors: tucker ei. Arterioscler Thromb Vasc Biol. 2018 Aug;38(8):1748-1760. doi: 10.1161/ATVBAHA.118.311193. Arterioscler Thromb Vasc Biol. 2018. PMID: 30354195 Free PMC article.
Contact Activation Inhibitor and Factor XI Antibody, AB023, Produces Safe, Dose-Dependent Anticoagulation in a Phase 1 First-In-Human Trial.
Lorentz CU, Verbout NG, Wallisch M, Hagen MW, Shatzel JJ, Olson SR, Puy C, Hinds MT, McCarty OJT, Gailani D, Gruber A, Tucker EI. Lorentz CU, et al. Among authors: tucker ei. Arterioscler Thromb Vasc Biol. 2019 Apr;39(4):799-809. doi: 10.1161/ATVBAHA.118.312328. Arterioscler Thromb Vasc Biol. 2019. PMID: 30700130 Free PMC article. Clinical Trial.
Antibody inhibition of contact factor XII reduces platelet deposition in a model of extracorporeal membrane oxygenator perfusion in nonhuman primates.
Wallisch M, Lorentz CU, Lakshmanan HHS, Johnson J, Carris MR, Puy C, Gailani D, Hinds MT, McCarty OJT, Gruber A, Tucker EI. Wallisch M, et al. Among authors: tucker ei. Res Pract Thromb Haemost. 2020 Feb 11;4(2):205-216. doi: 10.1002/rth2.12309. eCollection 2020 Feb. Res Pract Thromb Haemost. 2020. PMID: 32110750 Free PMC article.
Pharmacological targeting of coagulation factor XI mitigates the development of experimental atherosclerosis in low-density lipoprotein receptor-deficient mice.
Ngo ATP, Jordan KR, Mueller PA, Hagen MW, Reitsma SE, Puy C, Revenko AS, Lorentz CU, Tucker EI, Cheng Q, Hinds MT, Fazio S, Monia BP, Gailani D, Gruber A, Tavori H, McCarty OJT. Ngo ATP, et al. Among authors: tucker ei. J Thromb Haemost. 2021 Apr;19(4):1001-1017. doi: 10.1111/jth.15236. Epub 2021 Feb 10. J Thromb Haemost. 2021. PMID: 33421301 Free PMC article.
62 results