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Structure-Based Discovery and Development of Highly Potent Dihydroorotate Dehydrogenase Inhibitors for Malaria Chemoprevention.
Nie Z, Bonnert R, Tsien J, Deng X, Higgs C, El Mazouni F, Zhang X, Li R, Ho N, Feher V, Paulsen J, Shackleford DM, Katneni K, Chen G, Ng ACF, McInerney M, Wang W, Saunders J, Collins D, Yan D, Li P, Campbell M, Patil R, Ghoshal A, Mondal P, Kundu A, Chittimalla R, Mahadeva M, Kokkonda S, White J, Das R, Mukherjee P, Angulo-Barturen I, Jiménez-Díaz MB, Malmstrom R, Lawrenz M, Rodriguez-Granillo A, Rathod PK, Tomchick DR, Palmer MJ, Laleu B, Qin T, Charman SA, Phillips MA. Nie Z, et al. Among authors: tomchick dr. J Med Chem. 2025 Jan 9;68(1):590-637. doi: 10.1021/acs.jmedchem.4c02394. Epub 2024 Dec 22. J Med Chem. 2025. PMID: 39710971
Biochemical and structural insights into a 5' to 3' RNA ligase reveal a potential role in tRNA ligation.
Hu Y, Lopez VA, Xu H, Pfister JP, Song B, Servage KA, Sakurai M, Jones BT, Mendell JT, Wang T, Wu J, Lambowitz AM, Tomchick DR, Pawłowski K, Tagliabracci VS. Hu Y, et al. Among authors: tomchick dr. Proc Natl Acad Sci U S A. 2024 Oct 15;121(42):e2408249121. doi: 10.1073/pnas.2408249121. Epub 2024 Oct 10. Proc Natl Acad Sci U S A. 2024. PMID: 39388274 Free PMC article.
Identification of FDA-approved drugs that induce heart regeneration in mammals.
Ahmed MS, Nguyen NUN, Nakada Y, Hsu CC, Farag A, Lam NT, Wang P, Thet S, Menendez-Montes I, Elhelaly WM, Lou X, Secco I, Tomczyk M, Zentilin L, Pei J, Cui M, Dos Santos M, Liu X, Liu Y, Zaha D, Walcott G, Tomchick DR, Xing C, Zhang CC, Grishin NV, Giacca M, Zhang J, Sadek HA. Ahmed MS, et al. Among authors: tomchick dr. Nat Cardiovasc Res. 2024 Mar;3(3):372-388. doi: 10.1038/s44161-024-00450-y. Epub 2024 Mar 11. Nat Cardiovasc Res. 2024. PMID: 39183959 Free PMC article.
Biochemical and structural insights into a 5' to 3' RNA ligase reveal a potential role in tRNA ligation.
Hu Y, Lopez VA, Xu H, Pfister JP, Song B, Servage KA, Sakurai M, Jones BT, Mendell JT, Wang T, Wu J, Lambowitz AM, Tomchick DR, Pawłowski K, Tagliabracci VS. Hu Y, et al. Among authors: tomchick dr. bioRxiv [Preprint]. 2024 Apr 24:2024.04.24.590974. doi: 10.1101/2024.04.24.590974. bioRxiv. 2024. Update in: Proc Natl Acad Sci U S A. 2024 Oct 15;121(42):e2408249121. doi: 10.1073/pnas.2408249121 PMID: 38712170 Free PMC article. Updated. Preprint.
A domain-swapped CaMKII conformation facilitates linker-mediated allosteric regulation.
Nguyen BV, Özden C, Dong K, Torres-Ocampo AP, Dziedzic N, Flaherty D, Huang J, Sankura S, Abromson NL, Tomchick DR, Chen J, Garman SC, Stratton MM. Nguyen BV, et al. Among authors: tomchick dr. bioRxiv [Preprint]. 2024 Mar 27:2024.03.24.586494. doi: 10.1101/2024.03.24.586494. bioRxiv. 2024. PMID: 38585726 Free PMC article. Preprint.
Exploiting Bacterial Effector Proteins to Uncover Evolutionarily Conserved Antiviral Host Machinery.
Embry A, Baggett NS, Heisler DB, White A, de Jong MF, Kocsis BL, Tomchick DR, Alto NM, Gammon DB. Embry A, et al. Among authors: tomchick dr. bioRxiv [Preprint]. 2024 Jan 30:2024.01.29.577891. doi: 10.1101/2024.01.29.577891. bioRxiv. 2024. Update in: PLoS Pathog. 2024 May 16;20(5):e1012010. doi: 10.1371/journal.ppat.1012010 PMID: 38352400 Free PMC article. Updated. Preprint.
117 results