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Page 1
Kir2.1 mutations differentially increase the risk of flecainide proarrhythmia in Andersen Tawil Syndrome.
Cruz FM, Moreno-Manuel AI, Pérez PS, Ruiz-Robles JM, Socuellamos PG, Gutiérrez LK, Vera-Pedrosa ML, Gutierrez AT, Mondéjar Parreño G, Macías Á, Martínez-Carrascoso I, Bermúdez-Jiménez FJ, Arias Santiago S, Martínez de Benito F, Braza-Boils A, Valenzuela C, Morillo CA, Zorio E, Jiménez-Jaimez J, Jalife J. Cruz FM, et al. Among authors: moreno manuel ai. medRxiv [Preprint]. 2024 Dec 11:2024.12.10.24318629. doi: 10.1101/2024.12.10.24318629. medRxiv. 2024. PMID: 39711719 Free PMC article. Preprint.
Extracellular Kir2.1C122Y Mutant Upsets Kir2.1-PIP2 Bonds and Is Arrhythmogenic in Andersen-Tawil Syndrome.
Cruz FM, Macías Á, Moreno-Manuel AI, Gutiérrez LK, Vera-Pedrosa ML, Martínez-Carrascoso I, Sánchez Pérez P, Ruiz Robles JM, Bermúdez-Jiménez FJ, Díaz-Agustín A, Martínez de Benito F, Arias-Santiago S, Braza-Boils A, Martín-Martínez M, Gutierrez-Rodríguez M, Bernal JA, Zorio E, Jiménez-Jaimez J, Jalife J. Cruz FM, et al. Among authors: moreno manuel ai. Circ Res. 2024 Apr 12;134(8):e52-e71. doi: 10.1161/CIRCRESAHA.123.323895. Epub 2024 Mar 18. Circ Res. 2024. PMID: 38497220 Free article.
The Kir2.1E299V mutation increases atrial fibrillation vulnerability while protecting the ventricles against arrhythmias in a mouse model of short QT syndrome type 3.
Moreno-Manuel AI, Macías Á, Cruz FM, Gutiérrez LK, Martínez F, González-Guerra A, Martínez Carrascoso I, Bermúdez-Jimenez FJ, Sánchez-Pérez P, Vera-Pedrosa ML, Ruiz-Robles JM, Bernal JA, Jalife J. Moreno-Manuel AI, et al. Cardiovasc Res. 2024 Apr 30;120(5):490-505. doi: 10.1093/cvr/cvae019. Cardiovasc Res. 2024. PMID: 38261726 Free PMC article.
Extracellular cysteine disulfide bond break at Cys122 disrupts PIP2-dependent Kir2.1 channel function and leads to arrhythmias in Andersen-Tawil Syndrome.
Cruz FM, Macías Á, Moreno-Manuel AI, Gutiérrez LK, Vera-Pedrosa ML, Martínez-Carrascoso I, Pérez PS, Robles JMR, Bermúdez-Jiménez FJ, Díaz-Agustín A, de Benito FM, Santiago SA, Braza-Boils A, Martín-Martínez M, Gutierrez-Rodríguez M, Bernal JA, Zorio E, Jiménez-Jaimez J, Jalife J. Cruz FM, et al. Among authors: moreno manuel ai. bioRxiv [Preprint]. 2023 Jun 8:2023.06.07.544151. doi: 10.1101/2023.06.07.544151. bioRxiv. 2023. PMID: 37333254 Free PMC article. Preprint.
Kir2.1 dysfunction at the sarcolemma and the sarcoplasmic reticulum causes arrhythmias in a mouse model of Andersen-Tawil syndrome type 1.
Macías Á, González-Guerra A, Moreno-Manuel AI, Cruz FM, Gutiérrez LK, García-Quintáns N, Roche-Molina M, Bermúdez-Jiménez F, Andrés V, Vera-Pedrosa ML, Martínez-Carrascoso I, Bernal JA, Jalife J. Macías Á, et al. Among authors: moreno manuel ai. Nat Cardiovasc Res. 2022 Oct;1(10):900-917. doi: 10.1038/s44161-022-00145-2. Epub 2022 Oct 17. Nat Cardiovasc Res. 2022. PMID: 39195979 Free PMC article.