Heusser SA - Search Results

1

Conformational plasticity of human acid-sensing ion channel 1a.

Cahill J, Hartfield KA, Heusser SA, Poulsen MH, Yoshioka C, Pless SA, Baconguis I. Cahill J, et al. Among authors: heusser sa. bioRxiv [Preprint]. 2024 Dec 12:2024.12.11.628012. doi: 10.1101/2024.12.11.628012. bioRxiv. 2024. PMID: 39713315 Free PMC article. Preprint.

2

Dynamic conformational changes of acid-sensing ion channels in different desensitizing conditions.

Holm CM, Topaktas AB, Dannesboe J, Pless SA, Heusser SA. Holm CM, et al. Among authors: heusser sa. Biophys J. 2024 Jul 16;123(14):2122-2135. doi: 10.1016/j.bpj.2024.03.038. Epub 2024 Mar 28. Biophys J. 2024. PMID: 38549370

3

Protein semisynthesis underscores the role of a conserved lysine in activation and desensitization of acid-sensing ion channels.

Sarkar D, Galleano I, Heusser SA, Ou SY, Uzun GR, Khoo KK, van der Heden van Noort GJ, Harrison JS, Pless SA. Sarkar D, et al. Among authors: heusser sa. Cell Chem Biol. 2024 May 16;31(5):1000-1010.e6. doi: 10.1016/j.chembiol.2023.11.013. Epub 2023 Dec 18. Cell Chem Biol. 2024. PMID: 38113885

4

Structure-guided unlocking of Na_X reveals a non-selective tetrodotoxin-sensitive cation channel.

Noland CL, Chua HC, Kschonsak M, Heusser SA, Braun N, Chang T, Tam C, Tang J, Arthur CP, Ciferri C, Pless SA, Payandeh J. Noland CL, et al. Among authors: heusser sa. Nat Commun. 2022 Mar 17;13(1):1416. doi: 10.1038/s41467-022-28984-4. Nat Commun. 2022. PMID: 35301303 Free PMC article.

5

Conformational decoupling in acid-sensing ion channels uncovers mechanism and stoichiometry of PcTx1-mediated inhibition.

Heusser SA, Borg CB, Colding JM, Pless SA. Heusser SA, et al. Elife. 2022 Feb 14;11:e73384. doi: 10.7554/eLife.73384. Elife. 2022. PMID: 35156612 Free PMC article.

6

Acid-sensing ion channels as potential therapeutic targets.

Heusser SA, Pless SA. Heusser SA, et al. Trends Pharmacol Sci. 2021 Dec;42(12):1035-1050. doi: 10.1016/j.tips.2021.09.008. Epub 2021 Oct 18. Trends Pharmacol Sci. 2021. PMID: 34674886 Review.

7

Markov state models of proton- and pore-dependent activation in a pentameric ligand-gated ion channel.

Bergh C, Heusser SA, Howard R, Lindahl E. Bergh C, et al. Among authors: heusser sa. Elife. 2021 Oct 15;10:e68369. doi: 10.7554/eLife.68369. Elife. 2021. PMID: 34652272 Free PMC article.

8

Mechanism and site of action of big dynorphin on ASIC1a.

Borg CB, Braun N, Heusser SA, Bay Y, Weis D, Galleano I, Lund C, Tian W, Haugaard-Kedström LM, Bennett EP, Lynagh T, Strømgaard K, Andersen J, Pless SA. Borg CB, et al. Among authors: heusser sa. Proc Natl Acad Sci U S A. 2020 Mar 31;117(13):7447-7454. doi: 10.1073/pnas.1919323117. Epub 2020 Mar 12. Proc Natl Acad Sci U S A. 2020. PMID: 32165542 Free PMC article.

9

Allosteric potentiation of a ligand-gated ion channel is mediated by access to a deep membrane-facing cavity.

Heusser SA, Lycksell M, Wang X, McComas SE, Howard RJ, Lindahl E. Heusser SA, et al. Proc Natl Acad Sci U S A. 2018 Oct 16;115(42):10672-10677. doi: 10.1073/pnas.1809650115. Epub 2018 Oct 1. Proc Natl Acad Sci U S A. 2018. PMID: 30275330 Free PMC article.

10

Structural Basis for a Bimodal Allosteric Mechanism of General Anesthetic Modulation in Pentameric Ligand-Gated Ion Channels.

Fourati Z, Howard RJ, Heusser SA, Hu H, Ruza RR, Sauguet L, Lindahl E, Delarue M. Fourati Z, et al. Among authors: heusser sa. Cell Rep. 2018 Apr 24;23(4):993-1004. doi: 10.1016/j.celrep.2018.03.108. Cell Rep. 2018. PMID: 29694907 Free article.

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