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A multi-model approach identifies ALW-II-41-27 as a promising therapy for osteoarthritis-associated inflammation and endochondral ossification.
Ferrao Blanco MN, Lesage R, Kops N, Fahy N, Bekedam FT, Chavli A, Bastiaansen-Jenniskens YM, Geris L, Chambers MG, Pitsillides AA, Narcisi R, van Osch GJVM. Ferrao Blanco MN, et al. Among authors: lesage r. Heliyon. 2024 Dec 4;10(23):e40871. doi: 10.1016/j.heliyon.2024.e40871. eCollection 2024 Dec 15. Heliyon. 2024. PMID: 39717596 Free PMC article.
Dissecting the effects of preconditioning with inflammatory cytokines and hypoxia on the angiogenic potential of mesenchymal stromal cell (MSC)-derived soluble proteins and extracellular vesicles (EVs).
Gorgun C, Ceresa D, Lesage R, Villa F, Reverberi D, Balbi C, Santamaria S, Cortese K, Malatesta P, Geris L, Quarto R, Tasso R. Gorgun C, et al. Among authors: lesage r. Biomaterials. 2021 Feb;269:120633. doi: 10.1016/j.biomaterials.2020.120633. Epub 2020 Dec 28. Biomaterials. 2021. PMID: 33453634 Free article.
Verifying and Validating Quantitative Systems Pharmacology and In Silico Models in Drug Development: Current Needs, Gaps, and Challenges.
Musuamba FT, Bursi R, Manolis E, Karlsson K, Kulesza A, Courcelles E, Boissel JP, Lesage R, Crozatier C, Voisin EM, Rousseau CF, Marchal T, Alessandrello R, Geris L. Musuamba FT, et al. Among authors: lesage r. CPT Pharmacometrics Syst Pharmacol. 2020 Apr;9(4):195-197. doi: 10.1002/psp4.12504. Epub 2020 Apr 1. CPT Pharmacometrics Syst Pharmacol. 2020. PMID: 32237207 Free PMC article. No abstract available.
Scientific and regulatory evaluation of mechanistic in silico drug and disease models in drug development: Building model credibility.
Musuamba FT, Skottheim Rusten I, Lesage R, Russo G, Bursi R, Emili L, Wangorsch G, Manolis E, Karlsson KE, Kulesza A, Courcelles E, Boissel JP, Rousseau CF, Voisin EM, Alessandrello R, Curado N, Dall'ara E, Rodriguez B, Pappalardo F, Geris L. Musuamba FT, et al. Among authors: lesage r. CPT Pharmacometrics Syst Pharmacol. 2021 Aug;10(8):804-825. doi: 10.1002/psp4.12669. Epub 2021 Jul 13. CPT Pharmacometrics Syst Pharmacol. 2021. PMID: 34102034 Free PMC article.
74 results