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The solution structure of the first PHD finger of autoimmune regulator in complex with non-modified histone H3 tail reveals the antagonistic role of H3R2 methylation.
Chignola F, Gaetani M, Rebane A, Org T, Mollica L, Zucchelli C, Spitaleri A, Mannella V, Peterson P, Musco G. Chignola F, et al. Among authors: zucchelli c. Nucleic Acids Res. 2009 May;37(9):2951-61. doi: 10.1093/nar/gkp166. Epub 2009 Mar 17. Nucleic Acids Res. 2009. PMID: 19293276 Free PMC article.
The C-terminal PHDVC5HCH tandem domain of NSD2 is a combinatorial reader of unmodified H3K4 and tri-methylated H3K27 that regulates transcription of cell adhesion genes in multiple myeloma.
Berardi A, Kaestner CL, Ghitti M, Quilici G, Cocomazzi P, Li J, Ballabio F, Zucchelli C, Knapp S, Licht JD, Musco G. Berardi A, et al. Among authors: zucchelli c. Nucleic Acids Res. 2024 Dec 5:gkae1121. doi: 10.1093/nar/gkae1121. Online ahead of print. Nucleic Acids Res. 2024. PMID: 39656918
The acidic intrinsically disordered region of the inflammatory mediator HMGB1 mediates fuzzy interactions with CXCL12.
Mantonico MV, De Leo F, Quilici G, Colley LS, De Marchis F, Crippa M, Mezzapelle R, Schulte T, Zucchelli C, Pastorello C, Carmeno C, Caprioglio F, Ricagno S, Giachin G, Ghitti M, Bianchi ME, Musco G. Mantonico MV, et al. Among authors: zucchelli c. Nat Commun. 2024 Feb 8;15(1):1201. doi: 10.1038/s41467-024-45505-7. Nat Commun. 2024. PMID: 38331917 Free PMC article.
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