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436 results

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Page 1
PU.1 eviction at lymphocyte-specific chromatin domains mediates glucocorticoid response in acute lymphoblastic leukemia.
Beck D, Cao H, Tian F, Huang Y, Jiang M, Zhao H, Tai X, Xu W, Kosasih HJ, Kealy DJ, Zhao W, Taylor SJ, Couttas TA, Song G, Chacon-Fajardo D, Walia Y, Wang M, Dowle AA, Holding AN, Bridge KS, Zhang C, Wang J, Mi JQ, Lock RB, de Bock CE, Jing D. Beck D, et al. Among authors: lock rb. Nat Commun. 2024 Nov 8;15(1):9697. doi: 10.1038/s41467-024-54096-2. Nat Commun. 2024. PMID: 39516193 Free PMC article.
Lessons learned from 20 years of preclinical testing in pediatric cancers.
Smith MA, Houghton PJ, Lock RB, Maris JM, Gorlick R, Kurmasheva RT, Li XN, Teicher BA, Chuang JH, Dela Cruz FS, Dyer MA, Kung AL, Lloyd MW, Mossé YP, Stearns TM, Stewart EA, Bult CJ, Erickson SW. Smith MA, et al. Among authors: lock rb. Pharmacol Ther. 2024 Dec;264:108742. doi: 10.1016/j.pharmthera.2024.108742. Epub 2024 Nov 5. Pharmacol Ther. 2024. PMID: 39510293 Free article. Review.
The third generation AKR1C3-activated prodrug, ACHM-025, eradicates disease in preclinical models of aggressive T-cell acute lymphoblastic leukemia.
Toscan CE, McCalmont H, Ashoorzadeh A, Lin X, Fu Z, Doculara L, Kosasih HJ, Cadiz R, Zhou A, Williams S, Evans K, Khalili F, Cai R, Yeats KL, Gifford AJ, Pickford R, Mayoh C, Xie J, Henderson MJ, Trahair TN, Patterson AV, Smaill JB, de Bock CE, Lock RB. Toscan CE, et al. Among authors: lock rb. Blood Cancer J. 2024 Nov 6;14(1):192. doi: 10.1038/s41408-024-01180-x. Blood Cancer J. 2024. PMID: 39505850 Free PMC article.
TOPORS E3 ligase mediates resistance to hypomethylating agent cytotoxicity in acute myeloid leukemia cells.
Truong P, Shen S, Joshi S, Islam MI, Zhong L, Raftery MJ, Afrasiabi A, Alinejad-Rokny H, Nguyen M, Zou X, Bhuyan GS, Sarowar CH, Ghodousi ES, Stonehouse O, Mohamed S, Toscan CE, Connerty P, Kakadia PM, Bohlander SK, Michie KA, Larsson J, Lock RB, Walkley CR, Thoms JAI, Jolly CJ, Pimanda JE. Truong P, et al. Among authors: lock rb. Nat Commun. 2024 Aug 28;15(1):7360. doi: 10.1038/s41467-024-51646-6. Nat Commun. 2024. PMID: 39198401 Free PMC article.
An engineered human cardiac tissue model reveals contributions of systemic lupus erythematosus autoantibodies to myocardial injury.
Fleischer S, Nash TR, Tamargo MA, Lock RI, Venturini G, Morsink M, Graney PL, Li V, Lamberti MJ, Liberman M, Kim Y, Tavakol DN, Zhuang RZ, Whitehead J, Friedman RA, Soni RK, Seidman JG, Seidman CE, Geraldino-Pardilla L, Winchester R, Vunjak-Novakovic G. Fleischer S, et al. Among authors: lock ri. Nat Cardiovasc Res. 2024 Sep;3(9):1123-1139. doi: 10.1038/s44161-024-00525-w. Epub 2024 Aug 15. Nat Cardiovasc Res. 2024. PMID: 39195859 Free PMC article.
Modeling the Effects of Protracted Cosmic Radiation in a Human Organ-on-Chip Platform.
Tavakol DN, Nash TR, Kim Y, Graney PL, Liberman M, Fleischer S, Lock RI, O'Donnell A, Andrews L, Ning D, Yeager K, Harken A, Deoli N, Amundson SA, Garty G, Leong KW, Brenner DJ, Vunjak-Novakovic G. Tavakol DN, et al. Among authors: lock ri. Adv Sci (Weinh). 2024 Nov;11(42):e2401415. doi: 10.1002/advs.202401415. Epub 2024 Jul 4. Adv Sci (Weinh). 2024. PMID: 38965824 Free PMC article.
Precision-guided treatment in high-risk pediatric cancers.
Lau LMS, Khuong-Quang DA, Mayoh C, Wong M, Barahona P, Ajuyah P, Senapati A, Nagabushan S, Sherstyuk A, Altekoester AK, Fuentes-Bolanos NA, Yeung V, Sullivan A, Omer N, Diamond Y, Jessop S, Battaglia L, Zhukova N, Cui L, Lin A, Gifford AJ, Fleuren EDG, Dalla-Pozza L, Moore AS, Khaw SL, Eisenstat DD, Gottardo NG, Wood PJ, Tapp H, Alvaro F, McCowage G, Nicholls W, Hansford JR, Manoharan N, Kotecha RS, Mateos MK, Lock RB, Tyrrell V, Haber M, Trahair TN, Cowley MJ, Ekert PG, Marshall GM, Ziegler DS. Lau LMS, et al. Among authors: lock rb. Nat Med. 2024 Jul;30(7):1913-1922. doi: 10.1038/s41591-024-03044-0. Epub 2024 Jun 6. Nat Med. 2024. PMID: 38844796 Free PMC article.
436 results