Alkhalaf LM - Search Results

1

Alkhalaf LM, Arrowsmith C, Balskus EP, Bergamini G, Bhandari R, Chang CJ, Chen P, Chen X, Ciulli A, Cricco JA, Davis BG, Delbianco M, Dudareva N, Dueber E, Ferguson F, de Giuseppe PO, Hamachi I, Hammond MC, Hatzios SK, Do Heo W, Janet JP, Kamat SS, Knapp S, Krishnan Y, Lang K, Laraia L, Leveson-Gower RB, Li XD, Liu DR, Liu MF, London N, Mahanta N, Mayor-Ruiz C, Muir T, Murakami MT, Rhee HW, Robers M, Satz A, Schulman BA, Shen B, Shoichet B, Strauss E, Suzuki T, Tiwary P, Waldmann H, Ward TR, Weeks A, Weerapana E, Winter G. Alkhalaf LM, et al. Nat Chem Biol. 2025 Jan;21(1):6-15. doi: 10.1038/s41589-024-01802-2. Nat Chem Biol. 2025. PMID: 39719500 No abstract available.

2

Discovery and Biosynthesis of Persiathiacins: Unusual Polyglycosylated Thiopeptides Active Against Multidrug Resistant Tuberculosis.

Dashti Y, Mohammadipanah F, Zhang Y, Cerqueira Diaz PM, Vocat A, Zabala D, Fage CD, Romero-Canelon I, Bunk B, Spröer C, Alkhalaf LM, Overmann J, Cole ST, Challis GL. Dashti Y, et al. Among authors: alkhalaf lm. ACS Infect Dis. 2024 Sep 13;10(9):3378-3391. doi: 10.1021/acsinfecdis.4c00502. Epub 2024 Aug 27. ACS Infect Dis. 2024. PMID: 39189814 Free PMC article.

3

Native ESI-MS and Collision-Induced Unfolding (CIU) of the Complex between Bacterial Elongation Factor-Tu and the Antibiotic Enacyloxin IIa.

Baines C, Sargeant J, Fage CD, Pugh H, Alkhalaf LM, Challis GL, Oldham NJ. Baines C, et al. Among authors: alkhalaf lm. J Am Soc Mass Spectrom. 2024 Jul 3;35(7):1490-1496. doi: 10.1021/jasms.4c00087. Epub 2024 Jun 3. J Am Soc Mass Spectrom. 2024. PMID: 38830009 Free PMC article.

4

Antibiotic Skeletal Diversification via Differential Enoylreductase Recruitment and Module Iteration in trans-Acyltransferase Polyketide Synthases.

Jian X, Pang F, Hobson C, Jenner M, Alkhalaf LM, Challis GL. Jian X, et al. Among authors: alkhalaf lm. J Am Chem Soc. 2024 Mar 6;146(9):6114-6124. doi: 10.1021/jacs.3c13667. Epub 2024 Feb 23. J Am Chem Soc. 2024. PMID: 38389455 Free PMC article.

5

Parallelized gene cluster editing illuminates mechanisms of epoxyketone proteasome inhibitor biosynthesis.

Huang C, Zabala D, de Los Santos ELC, Song L, Corre C, Alkhalaf LM, Challis GL. Huang C, et al. Among authors: alkhalaf lm. Nucleic Acids Res. 2023 Feb 22;51(3):1488-1499. doi: 10.1093/nar/gkad009. Nucleic Acids Res. 2023. PMID: 36718812 Free PMC article.

6

Expanding the Substrate Scope of Nitrating Cytochrome P450 TxtE by Active Site Engineering of a Reductase Fusion.

Saroay R, Roiban GD, Alkhalaf LM, Challis GL. Saroay R, et al. Among authors: alkhalaf lm. Chembiochem. 2021 Jul 1;22(13):2262-2265. doi: 10.1002/cbic.202100145. Epub 2021 May 7. Chembiochem. 2021. PMID: 33851500 Free PMC article.

7

Molecular basis for control of antibiotic production by a bacterial hormone.

Zhou S, Bhukya H, Malet N, Harrison PJ, Rea D, Belousoff MJ, Venugopal H, Sydor PK, Styles KM, Song L, Cryle MJ, Alkhalaf LM, Fülöp V, Challis GL, Corre C. Zhou S, et al. Among authors: alkhalaf lm. Nature. 2021 Feb;590(7846):463-467. doi: 10.1038/s41586-021-03195-x. Epub 2021 Feb 3. Nature. 2021. PMID: 33536618

8

Catalytic Mechanism of Aromatic Nitration by Cytochrome P450 TxtE: Involvement of a Ferric-Peroxynitrite Intermediate.

Louka S, Barry SM, Heyes DJ, Mubarak MQE, Ali HS, Alkhalaf LM, Munro AW, Scrutton NS, Challis GL, de Visser SP. Louka S, et al. Among authors: alkhalaf lm. J Am Chem Soc. 2020 Sep 16;142(37):15764-15779. doi: 10.1021/jacs.0c05070. Epub 2020 Sep 2. J Am Chem Soc. 2020. PMID: 32811149 Free PMC article.

9

Binding of Distinct Substrate Conformations Enables Hydroxylation of Remote Sites in Thaxtomin D by Cytochrome P450 TxtC.

Alkhalaf LM, Barry SM, Rea D, Gallo A, Griffiths D, Lewandowski JR, Fulop V, Challis GL. Alkhalaf LM, et al. J Am Chem Soc. 2019 Jan 9;141(1):216-222. doi: 10.1021/jacs.8b08864. Epub 2018 Dec 19. J Am Chem Soc. 2019. PMID: 30516965

10

Desferrioxamine biosynthesis: diverse hydroxamate assembly by substrate-tolerant acyl transferase DesC.

Ronan JL, Kadi N, McMahon SA, Naismith JH, Alkhalaf LM, Challis GL. Ronan JL, et al. Among authors: alkhalaf lm. Philos Trans R Soc Lond B Biol Sci. 2018 Jun 5;373(1748):20170068. doi: 10.1098/rstb.2017.0068. Philos Trans R Soc Lond B Biol Sci. 2018. PMID: 29685972 Free PMC article.

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