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The TGF-β mimic TGM4 achieves cell specificity through combinatorial surface co-receptor binding.
Singh SP, Smyth DJ, Cunningham KT, Mukundan A, Byeon CH, Hinck CS, White MPJ, Ciancia C, Wąsowska N, Sanders A, Jin R, White RF, Lilla S, Zanivan S, Schoenherr C, Inman GJ, van Dinther M, Ten Dijke P, Hinck AP, Maizels RM. Singh SP, et al. Among authors: ten dijke p. EMBO Rep. 2024 Nov 28. doi: 10.1038/s44319-024-00323-2. Online ahead of print. EMBO Rep. 2024. PMID: 39609640 Free article.
ECM1 attenuates hepatic fibrosis by interfering with mediators of latent TGF-β1 activation.
Link F, Li Y, Zhao J, Munker S, Fan W, Nwosu ZC, Yao Y, Wang S, Huang C, Liebe R, Hammad S, Liu H, Shao C, Gao C, Sun B, Török NJ, Ding H, Ebert MP, Weng H, Ten Dijke P, Drasdo D, Dooley S, Wang S. Link F, et al. Among authors: ten dijke p. Gut. 2024 Oct 24:gutjnl-2024-333213. doi: 10.1136/gutjnl-2024-333213. Online ahead of print. Gut. 2024. PMID: 39448254
TGM6, a helminth secretory product, mimics TGF-β binding to TβRII to antagonize TGF-β signaling in fibroblasts.
White SE, Schwartze TA, Mukundan A, Schoenherr C, Singh SP, van Dinther M, Cunningham KT, White MPJ, Campion T, Pritchard J, Hinck CS, Ten Dijke P, Inman G, Maizels RM, Hinck AP. White SE, et al. Among authors: ten dijke p. bioRxiv [Preprint]. 2023 Dec 23:2023.12.22.573140. doi: 10.1101/2023.12.22.573140. bioRxiv. 2023. PMID: 38187573 Free PMC article. Preprint.
The helminth TGF-β mimic TGM4 is a modular ligand that binds CD44, CD49d and TGF-β receptors to preferentially target myeloid cells.
Singh SP, Smyth DJ, Cunningham K, Mukundan A, Byeon CH, Hinck CS, White MPJ, Ciancia C, Wosowska N, Sanders A, Jin R, Lilla S, Zanivan S, Schoenherr C, Inman G, van Dinther M, Ten Dijke P, Hinck AP, Maizels RM. Singh SP, et al. Among authors: ten dijke p. bioRxiv [Preprint]. 2023 Nov 15:2023.11.13.566701. doi: 10.1101/2023.11.13.566701. bioRxiv. 2023. PMID: 38014296 Free PMC article. Preprint.
469 results