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Page 1
Development and Discovery of a Selective Degrader of Casein Kinases 1 δ/ε.
Haag A, Němec V, Janovská P, Bartošíková J, Adhikari B, Müller J, Schwalm MP, Čada Š, Ohmayer U, Daub H, Kim Y, Born F, Wolf E, Bryja V, Knapp S. Haag A, et al. Among authors: janovska p. J Med Chem. 2025 Jan 9;68(1):506-530. doi: 10.1021/acs.jmedchem.4c02201. Epub 2024 Dec 27. J Med Chem. 2025. PMID: 39729064
Discovery of Potent and Exquisitely Selective Inhibitors of Kinase CK1 with Tunable Isoform Selectivity.
Němec V, Khirsariya P, Janovská P, Moyano PM, Maier L, Procházková P, Kebková P, Gybel' T, Berger BT, Chaikuad A, Reinecke M, Kuster B, Knapp S, Bryja V, Paruch K. Němec V, et al. Among authors: janovska p. Angew Chem Int Ed Engl. 2023 Mar 6;62(11):e202217532. doi: 10.1002/anie.202217532. Epub 2023 Feb 2. Angew Chem Int Ed Engl. 2023. PMID: 36625768
Role of casein kinase 1 in the amoeboid migration of B-cell leukemic and lymphoma cells: A quantitative live imaging in the confined environment.
Čada Š, Vondálová Blanářová O, Gömoryová K, Mikulová A, Bačovská P, Zezula N, Kumari Jadaun A, Janovská P, Plešingerová H, Bryja V. Čada Š, et al. Among authors: janovska p. Front Cell Dev Biol. 2022 Dec 6;10:911966. doi: 10.3389/fcell.2022.911966. eCollection 2022. Front Cell Dev Biol. 2022. PMID: 36561363 Free PMC article.
Lyn Phosphorylates and Controls ROR1 Surface Dynamics During Chemotaxis of CLL Cells.
Dave Z, Vondálová Blanářová O, Čada Š, Janovská P, Zezula N, Běhal M, Hanáková K, Ganji SR, Krejci P, Gömöryová K, Peschelová H, Šmída M, Zdráhal Z, Pavlová Š, Kotašková J, Pospíšilová Š, Bryja V. Dave Z, et al. Among authors: janovska p. Front Cell Dev Biol. 2022 Feb 28;10:838871. doi: 10.3389/fcell.2022.838871. eCollection 2022. Front Cell Dev Biol. 2022. PMID: 35295854 Free PMC article.
Casein kinase 1 is a therapeutic target in chronic lymphocytic leukemia.
Janovska P, Verner J, Kohoutek J, Bryjova L, Gregorova M, Dzimkova M, Skabrahova H, Radaszkiewicz T, Ovesna P, Vondalova Blanarova O, Nemcova T, Hoferova Z, Vasickova K, Smyckova L, Egle A, Pavlova S, Poppova L, Plevova K, Pospisilova S, Bryja V. Janovska P, et al. Blood. 2018 Mar 15;131(11):1206-1218. doi: 10.1182/blood-2017-05-786947. Epub 2018 Jan 9. Blood. 2018. PMID: 29317454 Free article.
The planar cell polarity pathway drives pathogenesis of chronic lymphocytic leukemia by the regulation of B-lymphocyte migration.
Kaucká M, Plevová K, Pavlová S, Janovská P, Mishra A, Verner J, Procházková J, Krejcí P, Kotasková J, Ovesná P, Tichy B, Brychtová Y, Doubek M, Kozubík A, Mayer J, Pospísilová S, Bryja V. Kaucká M, et al. Among authors: janovska p. Cancer Res. 2013 Mar 1;73(5):1491-501. doi: 10.1158/0008-5472.CAN-12-1752. Epub 2013 Jan 21. Cancer Res. 2013. PMID: 23338609
Unveiling the dynamics and molecular landscape of a rare chronic lymphocytic leukemia subpopulation driving refractoriness: insights from single-cell RNA sequencing.
Kurucova T, Reblova K, Janovska P, Porc JP, Navrkalova V, Pavlova S, Malcikova J, Plevova K, Tichy B, Doubek M, Bryja V, Kotaskova J, Pospisilova S. Kurucova T, et al. Among authors: janovska p. Mol Oncol. 2024 Oct;18(10):2541-2553. doi: 10.1002/1878-0261.13663. Epub 2024 May 21. Mol Oncol. 2024. PMID: 38770541 Free PMC article.
62 results