Rapacz A - Search Results

1

Synthesis, Anticonvulsant, Antinociceptive Activity and Preliminary Safety Evaluations of Novel Hybrid Imidazolidine-2,4-dione Derivatives with Morpholine Moiety.

Czopek A, Byrtus H, Góra M, Rapacz A, Sałat K, Koczurkiewicz-Adamczyk P, Pękala E, Obniska J, Kamiński K. Czopek A, et al. Among authors: rapacz a. ChemMedChem. 2024 Dec 31:e202400612. doi: 10.1002/cmdc.202400612. Online ahead of print. ChemMedChem. 2024. PMID: 39739594

2

Synthesis and Determination of Lipophilicity, Anticonvulsant Activity, and Preliminary Safety of 3-Substituted and 3-Unsubstituted N-[(4-Arylpiperazin-1-yl)alkyl]pyrrolidine-2,5-dione Derivatives.

Rybka S, Obniska J, Żmudzki P, Koczurkiewicz P, Wójcik-Pszczoła K, Pękala E, Bryła A, Rapacz A. Rybka S, et al. Among authors: rapacz a. ChemMedChem. 2017 Nov 22;12(22):1848-1856. doi: 10.1002/cmdc.201700539. Epub 2017 Nov 14. ChemMedChem. 2017. PMID: 29045762

3

Synthesis, Anticonvulsant and Antinociceptive Activity of New Hybrid Compounds: Derivatives of 3-(3-Methylthiophen-2-yl)-pyrrolidine-2,5-dione.

Góra M, Czopek A, Rapacz A, Dziubina A, Głuch-Lutwin M, Mordyl B, Obniska J. Góra M, et al. Among authors: rapacz a. Int J Mol Sci. 2020 Aug 11;21(16):5750. doi: 10.3390/ijms21165750. Int J Mol Sci. 2020. PMID: 32796594 Free PMC article.

4

Design, Synthesis and Biological Activity of New Amides Derived from 3-Benzhydryl and 3-sec-Butyl-2,5-dioxo-pyrrolidin-1-yl-acetic Acid.

Góra M, Czopek A, Rapacz A, Giza A, Koczurkiewicz-Adamczyk P, Pękala E, Obniska J, Kamiński K. Góra M, et al. Among authors: rapacz a. ChemMedChem. 2021 May 18;16(10):1619-1630. doi: 10.1002/cmdc.202001007. Epub 2021 Mar 2. ChemMedChem. 2021. PMID: 33539029

5

Synthesis, physicochemical, and anticonvulsant properties of new N-Mannich bases derived from pyrrolidine-2,5-dione and its 3-methyl analog.

Rybka S, Obniska J, Rapacz A, Filipek B, Kamiński K. Rybka S, et al. Among authors: rapacz a. Arch Pharm (Weinheim). 2014 Oct;347(10):768-76. doi: 10.1002/ardp.201400152. Epub 2014 Aug 19. Arch Pharm (Weinheim). 2014. PMID: 25139813

6

Antinociceptive properties of N-Mannich bases derived from 3-substituted pyrrolidine-2,5-dione in the formalin model of persistent pain in mice.

Obniska J, Sałat K, Librowski T, Kamiński K, Lipkowska A, Wiklik B, Rybka S, Rapacz A. Obniska J, et al. Among authors: rapacz a. Pharmacol Rep. 2015 Feb;67(1):63-8. doi: 10.1016/j.pharep.2014.08.002. Epub 2014 Aug 20. Pharmacol Rep. 2015. PMID: 25560577

7

Design, synthesis and biological activity of new amides derived from 3-methyl-3-phenyl-2,5-dioxo-pyrrolidin-1-yl-acetic acid.

Obniska J, Rapacz A, Rybka S, Powroźnik B, Pękala E, Filipek B, Żmudzki P, Kamiński K. Obniska J, et al. Among authors: rapacz a. Eur J Med Chem. 2015 Sep 18;102:14-25. doi: 10.1016/j.ejmech.2015.07.017. Epub 2015 Jul 13. Eur J Med Chem. 2015. PMID: 26241874

8

Synthesis and anticonvulsant activity of new N-mannich bases derived from benzhydryl- and isopropyl-pyrrolidine-2,5-dione.

Rybka S, Obniska J, Rapacz A, Filipek B, Żmudzki P. Rybka S, et al. Among authors: rapacz a. J Enzyme Inhib Med Chem. 2016 Dec;31(6):1038-47. doi: 10.3109/14756366.2015.1088842. Epub 2015 Sep 25. J Enzyme Inhib Med Chem. 2016. PMID: 26406340 Free article.

9

Evaluation of anticonvulsant and antinociceptive properties of new N-Mannich bases derived from pyrrolidine-2,5-dione and 3-methylpyrrolidine-2,5-dione.

Rapacz A, Rybka S, Obniska J, Sałat K, Powroźnik B, Pękala E, Filipek B. Rapacz A, et al. Naunyn Schmiedebergs Arch Pharmacol. 2016 Mar;389(3):339-48. doi: 10.1007/s00210-015-1194-2. Epub 2015 Dec 9. Naunyn Schmiedebergs Arch Pharmacol. 2016. PMID: 26650502 Free PMC article.

10

New hybrid molecules with anticonvulsant and antinociceptive activity derived from 3-methyl- or 3,3-dimethyl-1-[1-oxo-1-(4-phenylpiperazin-1-yl)propan-2-yl]pyrrolidine-2,5-diones.

Kamiński K, Zagaja M, Rapacz A, Łuszczki JJ, Andres-Mach M, Abram M, Obniska J. Kamiński K, et al. Among authors: rapacz a. Bioorg Med Chem. 2016 Feb 15;24(4):606-18. doi: 10.1016/j.bmc.2015.12.027. Epub 2015 Dec 18. Bioorg Med Chem. 2016. PMID: 26746343

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