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Structure-guided design and synthesis of C22- and C32-modified FK520 analogs with enhanced activity against human pathogenic fungi.
Dome PA, Jeong P, Nam G, Jang H, Rivera A, Floyd Averette A, Park E, Liao TC, Ciofani M, Wu J, Chi JA, Venters RA, Park HJ, Steinbach WJ, Juvvadi PR, Heitman J, Hong J. Dome PA, et al. Among authors: hong j. Proc Natl Acad Sci U S A. 2025 Jan 7;122(1):e2419883121. doi: 10.1073/pnas.2419883121. Epub 2024 Dec 31. Proc Natl Acad Sci U S A. 2025. PMID: 39739817
Methotrexate recognition by the human reduced folate carrier SLC19A1.
Wright NJ, Fedor JG, Zhang H, Jeong P, Suo Y, Yoo J, Hong J, Im W, Lee SY. Wright NJ, et al. Among authors: hong j. Nature. 2022 Sep;609(7929):1056-1062. doi: 10.1038/s41586-022-05168-0. Epub 2022 Sep 7. Nature. 2022. PMID: 36071163 Free PMC article.
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