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Generic residue numbering of the GAIN domain of adhesion GPCRs.
Seufert F, Pérez-Hernández G, Pándy-Szekeres G, Guixà-González R, Langenhan T, Gloriam DE, Hildebrand PW. Seufert F, et al. Among authors: perez hernandez g. Nat Commun. 2025 Jan 2;16(1):246. doi: 10.1038/s41467-024-55466-6. Nat Commun. 2025. PMID: 39747076 Free PMC article.
Tethered agonist exposure in intact adhesion/class B2 GPCRs through intrinsic structural flexibility of the GAIN domain.
Beliu G, Altrichter S, Guixà-González R, Hemberger M, Brauer I, Dahse AK, Scholz N, Wieduwild R, Kuhlemann A, Batebi H, Seufert F, Pérez-Hernández G, Hildebrand PW, Sauer M, Langenhan T. Beliu G, et al. Mol Cell. 2021 Mar 4;81(5):905-921.e5. doi: 10.1016/j.molcel.2020.12.042. Epub 2021 Jan 25. Mol Cell. 2021. PMID: 33497605 Free article.
Time-resolved cryo-EM of G-protein activation by a GPCR.
Papasergi-Scott MM, Pérez-Hernández G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G. Papasergi-Scott MM, et al. Among authors: perez hernandez g. Nature. 2024 May;629(8014):1182-1191. doi: 10.1038/s41586-024-07153-1. Epub 2024 Mar 13. Nature. 2024. PMID: 38480881 Free PMC article.
Mechanistic insights into G-protein coupling with an agonist-bound G-protein-coupled receptor.
Batebi H, Pérez-Hernández G, Rahman SN, Lan B, Kamprad A, Shi M, Speck D, Tiemann JKS, Guixà-González R, Reinhardt F, Stadler PF, Papasergi-Scott MM, Skiniotis G, Scheerer P, Kobilka BK, Mathiesen JM, Liu X, Hildebrand PW. Batebi H, et al. Among authors: perez hernandez g. Nat Struct Mol Biol. 2024 Nov;31(11):1692-1701. doi: 10.1038/s41594-024-01334-2. Epub 2024 Jun 12. Nat Struct Mol Biol. 2024. PMID: 38867113
Time-resolved cryo-EM of G protein activation by a GPCR.
Papasergi-Scott MM, Pérez-Hernández G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G. Papasergi-Scott MM, et al. bioRxiv [Preprint]. 2023 Mar 21:2023.03.20.533387. doi: 10.1101/2023.03.20.533387. bioRxiv. 2023. Update in: Nature. 2024 May;629(8014):1182-1191. doi: 10.1038/s41586-024-07153-1 PMID: 36993214 Free PMC article. Updated. Preprint.
Lessons learned during the journey of data: from experiment to model for predicting kinase affinity, selectivity, polypharmacology, and resistance.
López-Ríos de Castro R, Rodríguez-Guerra J, Schaller D, Kimber TB, Taylor C, White JB, Backenköhler M, Payne A, Kaminow B, Pulido I, Singh S, Kramer PL, Pérez-Hernández G, Volkamer A, Chodera JD. López-Ríos de Castro R, et al. Among authors: perez hernandez g. bioRxiv [Preprint]. 2024 Sep 10:2024.09.10.612176. doi: 10.1101/2024.09.10.612176. bioRxiv. 2024. PMID: 39314436 Free PMC article. Preprint.
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