Obika S - Search Results

1

Multispanning membrane protein SIDT2 increases knockdown activity of gapmer antisense oligonucleotides.

Kusumoto K, Sasaki K, Uchida Y, Utsumi A, Yoshida T, Obika S, Inoue T, Okuhira K. Kusumoto K, et al. Among authors: obika s. Sci Rep. 2025 Jan 2;15(1):586. doi: 10.1038/s41598-024-84310-6. Sci Rep. 2025. PMID: 39747556 Free PMC article.

2

Estimated number of off-target candidate sites for antisense oligonucleotides in human mRNA sequences.

Yoshida T, Naito Y, Sasaki K, Uchida E, Sato Y, Naito M, Kawanishi T, Obika S, Inoue T. Yoshida T, et al. Among authors: obika s. Genes Cells. 2018 Jun;23(6):448-455. doi: 10.1111/gtc.12587. Epub 2018 Apr 18. Genes Cells. 2018. PMID: 29667281 Free article.

3

Evaluation of off-target effects of gapmer antisense oligonucleotides using human cells.

Yoshida T, Naito Y, Yasuhara H, Sasaki K, Kawaji H, Kawai J, Naito M, Okuda H, Obika S, Inoue T. Yoshida T, et al. Among authors: obika s. Genes Cells. 2019 Dec;24(12):827-835. doi: 10.1111/gtc.12730. Epub 2019 Nov 12. Genes Cells. 2019. PMID: 31637814 Free PMC article.

4

Reduction of Off-Target Effects of Gapmer Antisense Oligonucleotides by Oligonucleotide Extension.

Yasuhara H, Yoshida T, Sasaki K, Obika S, Inoue T. Yasuhara H, et al. Among authors: obika s. Mol Diagn Ther. 2022 Jan;26(1):117-127. doi: 10.1007/s40291-021-00573-z. Epub 2022 Jan 7. Mol Diagn Ther. 2022. PMID: 34994962 Free PMC article.

5

Identification of nucleobase chemical modifications that reduce the hepatotoxicity of gapmer antisense oligonucleotides.

Yoshida T, Morihiro K, Naito Y, Mikami A, Kasahara Y, Inoue T, Obika S. Yoshida T, et al. Among authors: obika s. Nucleic Acids Res. 2022 Jul 22;50(13):7224-7234. doi: 10.1093/nar/gkac562. Nucleic Acids Res. 2022. PMID: 35801870 Free PMC article.

6

Introduction of sugar-modified nucleotides into CpG-containing antisense oligonucleotides inhibits TLR9 activation.

Yoshida T, Hagihara T, Uchida Y, Horiuchi Y, Sasaki K, Yamamoto T, Yamashita T, Goda Y, Saito Y, Yamaguchi T, Obika S, Yamamoto S, Inoue T. Yoshida T, et al. Among authors: obika s. Sci Rep. 2024 May 21;14(1):11540. doi: 10.1038/s41598-024-61666-3. Sci Rep. 2024. PMID: 38773176 Free PMC article.

7

Synthesis and Properties of Nucleobase-Sugar Dual Modified Nucleic Acids: 2'-OMe-RNA and scpBNA Bearing a 5-Hydroxycytosine Nucleobase.

Sakurai Y, Yamaguchi T, Yoshida T, Horiba M, Inoue T, Obika S. Sakurai Y, et al. Among authors: obika s. J Org Chem. 2023 Jan 6;88(1):154-162. doi: 10.1021/acs.joc.2c02038. Epub 2022 Dec 15. J Org Chem. 2023. PMID: 36520114

8

Drug Metabolism and Pharmacokinetics of Antisense Oligonucleotide Therapeutics: Typical Profiles, Evaluation Approaches, and Points to Consider Compared with Small Molecule Drugs.

Takakusa H, Iwazaki N, Nishikawa M, Yoshida T, Obika S, Inoue T. Takakusa H, et al. Among authors: obika s. Nucleic Acid Ther. 2023 Apr;33(2):83-94. doi: 10.1089/nat.2022.0054. Epub 2023 Feb 3. Nucleic Acid Ther. 2023. PMID: 36735616 Free PMC article. Review.

9

Separation and Characterization of Therapeutic Oligonucleotide Isomer Impurities by Cyclic Ion Mobility Mass Spectrometry.

Omuro S, Yamaguchi T, Kawase T, Hirose K, Yoshida T, Inoue T, Obika S. Omuro S, et al. Among authors: obika s. J Am Soc Mass Spectrom. 2024 Sep 4;35(9):2156-2164. doi: 10.1021/jasms.4c00197. Epub 2024 Jul 31. J Am Soc Mass Spectrom. 2024. PMID: 39082615 Free PMC article.

10

Design and evaluation of locked nucleic acid-based splice-switching oligonucleotides in vitro.

Shimo T, Tachibana K, Saito K, Yoshida T, Tomita E, Waki R, Yamamoto T, Doi T, Inoue T, Kawakami J, Obika S. Shimo T, et al. Among authors: obika s. Nucleic Acids Res. 2014 Jul;42(12):8174-87. doi: 10.1093/nar/gku512. Epub 2014 Jun 16. Nucleic Acids Res. 2014. PMID: 24935206 Free PMC article.

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