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Coumarin-chalcone hybrid LM-021 and indole derivative NC009-1 targeting inflammation and oxidative stress to protect BE(2)-M17 cells against α-synuclein toxicity.
Yang PN, Chen WL, Lee JW, Lin CH, Chen YR, Lin CY, Lin W, Yao CF, Wu YR, Chang KH, Chen CM, Lee-Chen GJ. Yang PN, et al. Among authors: lin cy, lin ch, lin w. Aging (Albany NY). 2023 Aug 11;15(16):8061-8089. doi: 10.18632/aging.204954. Epub 2023 Aug 11. Aging (Albany NY). 2023. PMID: 37578928 Free PMC article.
Coumarin-chalcone derivatives as dual NLRP1 and NLRP3 inflammasome inhibitors targeting oxidative stress and inflammation in neurotoxin-induced HMC3 and BE(2)-M17 cell models of Parkinson's disease.
Lin TH, Chiu YJ, Lin CH, Chen YR, Lin W, Wu YR, Chang KH, Chen CM, Lee-Chen GJ. Lin TH, et al. Among authors: lin ch, lin w. Front Aging Neurosci. 2024 Oct 1;16:1437138. doi: 10.3389/fnagi.2024.1437138. eCollection 2024. Front Aging Neurosci. 2024. PMID: 39411284 Free PMC article.
Aqueous Extract of Paeonia lactiflora and Paeoniflorin as Aggregation Reducers Targeting Chaperones in Cell Models of Spinocerebellar Ataxia 3.
Chang KH, Chen WL, Lee LC, Lin CH, Kung PJ, Lin TH, Wu YC, Wu YR, Chen YC, Lee-Chen GJ, Chen CM. Chang KH, et al. Among authors: lin ch, lin th. Evid Based Complement Alternat Med. 2013;2013:471659. doi: 10.1155/2013/471659. Epub 2013 Feb 25. Evid Based Complement Alternat Med. 2013. PMID: 23533486 Free PMC article.
Aqueous extract of Glycyrrhiza inflata inhibits aggregation by upregulating PPARGC1A and NFE2L2-ARE pathways in cell models of spinocerebellar ataxia 3.
Chen CM, Weng YT, Chen WL, Lin TH, Chao CY, Lin CH, Chen IC, Lee LC, Lin HY, Wu YR, Chen YC, Chang KH, Tang HY, Cheng ML, Lee-Chen GJ, Lin JY. Chen CM, et al. Among authors: lin ch, lin hy, lin th, lin jy. Free Radic Biol Med. 2014 Jun;71:339-350. doi: 10.1016/j.freeradbiomed.2014.03.023. Epub 2014 Mar 25. Free Radic Biol Med. 2014. PMID: 24675225
The potential of synthetic indolylquinoline derivatives for Aβ aggregation reduction by chemical chaperone activity.
Chang KH, Chiu YJ, Chen SL, Huang CH, Lin CH, Lin TH, Lee CM, Ramesh C, Wu CH, Huang CC, Fung HC, Chen YC, Lin JY, Yao CF, Huang HJ, Lee-Chen GJ, Lee MC, Hsieh-Li HM. Chang KH, et al. Among authors: lin ch, lin th, lin jy. Neuropharmacology. 2016 Feb;101:309-19. doi: 10.1016/j.neuropharm.2015.09.005. Epub 2015 Sep 8. Neuropharmacology. 2016. PMID: 26362358
The aqueous extract of Glycyrrhiza inflata can upregulate unfolded protein response-mediated chaperones to reduce tau misfolding in cell models of Alzheimer's disease.
Chang KH, Chen IC, Lin HY, Chen HC, Lin CH, Lin TH, Weng YT, Chao CY, Wu YR, Lin JY, Lee-Chen GJ, Chen CM. Chang KH, et al. Among authors: lin ch, lin hy, lin th, lin jy. Drug Des Devel Ther. 2016 Feb 29;10:885-96. doi: 10.2147/DDDT.S96454. eCollection 2016. Drug Des Devel Ther. 2016. PMID: 27013866 Free PMC article.
Functional properties of LRRK2 mutations in Taiwanese Parkinson disease.
Chang KH, Chen CM, Lin CH, Chang WT, Jiang PR, Hsiao YC, Wu YR, Lee-Chen GJ. Chang KH, et al. Among authors: lin ch. J Formos Med Assoc. 2017 Mar;116(3):197-204. doi: 10.1016/j.jfma.2016.04.009. Epub 2016 Jul 14. J Formos Med Assoc. 2017. PMID: 27423549 Free article.
6,645 results