Tu J - Search Results

1

Lanosterol 14α-Demethylase (CYP51)/Heat Shock Protein 90 (Hsp90) Dual Inhibitors for the Treatment of Invasive Candidiasis.

Zhang M, Yang W, Liu N, Tu J, Lin J, Dong G, Zhao D, Sheng C. Zhang M, et al. Among authors: tu j. J Med Chem. 2025 Jan 23;68(2):1668-1681. doi: 10.1021/acs.jmedchem.4c02305. Epub 2025 Jan 4. J Med Chem. 2025. PMID: 39754582

2

Emerging New Targets for the Treatment of Resistant Fungal Infections.

Liu N, Tu J, Dong G, Wang Y, Sheng C. Liu N, et al. Among authors: tu j. J Med Chem. 2018 Jul 12;61(13):5484-5511. doi: 10.1021/acs.jmedchem.7b01413. Epub 2018 Jan 16. J Med Chem. 2018. PMID: 29294275 Review.

3

Discovery of Carboline Derivatives as Potent Antifungal Agents for the Treatment of Cryptococcal Meningitis.

Tu J, Li Z, Jiang Y, Ji C, Han G, Wang Y, Liu N, Sheng C. Tu J, et al. J Med Chem. 2019 Mar 14;62(5):2376-2389. doi: 10.1021/acs.jmedchem.8b01598. Epub 2019 Feb 22. J Med Chem. 2019. PMID: 30753074

4

Discovery of Novel Fungal Lanosterol 14α-Demethylase (CYP51)/Histone Deacetylase Dual Inhibitors to Treat Azole-Resistant Candidiasis.

Han G, Liu N, Li C, Tu J, Li Z, Sheng C. Han G, et al. Among authors: tu j. J Med Chem. 2020 May 28;63(10):5341-5359. doi: 10.1021/acs.jmedchem.0c00102. Epub 2020 May 9. J Med Chem. 2020. PMID: 32347094

5

Targeting fungal virulence factor by small molecules: Structure-based discovery of novel secreted aspartic protease 2 (SAP2) inhibitors.

Li C, Liu Y, Wu S, Han G, Tu J, Dong G, Liu N, Sheng C. Li C, et al. Among authors: tu j. Eur J Med Chem. 2020 Sep 1;201:112515. doi: 10.1016/j.ejmech.2020.112515. Epub 2020 Jun 21. Eur J Med Chem. 2020. PMID: 32623209

6

Novel Carboline Fungal Histone Deacetylase (HDAC) Inhibitors for Combinational Treatment of Azole-Resistant Candidiasis.

Li Z, Tu J, Han G, Liu N, Sheng C. Li Z, et al. Among authors: tu j. J Med Chem. 2021 Jan 28;64(2):1116-1126. doi: 10.1021/acs.jmedchem.0c01763. Epub 2020 Dec 27. J Med Chem. 2021. PMID: 33356256

7

Lanosterol 14α-demethylase (CYP51)/histone deacetylase (HDAC) dual inhibitors for treatment of Candida tropicalis and Cryptococcus neoformans infections.

Zhu T, Chen X, Li C, Tu J, Liu N, Xu D, Sheng C. Zhu T, et al. Among authors: tu j. Eur J Med Chem. 2021 Oct 5;221:113524. doi: 10.1016/j.ejmech.2021.113524. Epub 2021 May 7. Eur J Med Chem. 2021. PMID: 33992927

8

Heat shock protein 90 (Hsp90)/Histone deacetylase (HDAC) dual inhibitors for the treatment of azoles-resistant Candida albicans.

Li C, Tu J, Han G, Liu N, Sheng C. Li C, et al. Among authors: tu j. Eur J Med Chem. 2022 Jan 5;227:113961. doi: 10.1016/j.ejmech.2021.113961. Epub 2021 Oct 29. Eur J Med Chem. 2022. PMID: 34742014

9

Discovery of Novel Sertraline Derivatives as Potent Anti-Cryptococcus Agents.

Li W, Yun Z, Ji C, Tu J, Yang W, Li J, Liu N, Sheng C. Li W, et al. Among authors: tu j. J Med Chem. 2022 May 12;65(9):6541-6554. doi: 10.1021/acs.jmedchem.1c01845. Epub 2022 Mar 6. J Med Chem. 2022. PMID: 35253435

10

Discovery of BRD4-HDAC Dual Inhibitors with Improved Fungal Selectivity and Potent Synergistic Antifungal Activity against Fluconazole-Resistant Candida albicans.

Li Z, Huang Y, Tu J, Yang W, Liu N, Wang W, Sheng C. Li Z, et al. Among authors: tu j. J Med Chem. 2023 Apr 27;66(8):5950-5964. doi: 10.1021/acs.jmedchem.3c00165. Epub 2023 Apr 10. J Med Chem. 2023. PMID: 37037787

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