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Fragment-to-Lead Medicinal Chemistry Publications in 2023.
Holvey RS, Erlanson DA, de Esch IJP, Farkaš B, Jahnke W, Nishiyama T, Woodhead AJ. Holvey RS, et al. Among authors: erlanson da. J Med Chem. 2025 Jan 6. doi: 10.1021/acs.jmedchem.4c02593. Online ahead of print. J Med Chem. 2025. PMID: 39761118 Review.
Fragment-to-Lead Medicinal Chemistry Publications in 2022.
Woodhead AJ, Erlanson DA, de Esch IJP, Holvey RS, Jahnke W, Pathuri P. Woodhead AJ, et al. Among authors: erlanson da. J Med Chem. 2024 Feb 22;67(4):2287-2304. doi: 10.1021/acs.jmedchem.3c02070. Epub 2024 Jan 30. J Med Chem. 2024. PMID: 38289623 Review.
Fragment-to-Lead Medicinal Chemistry Publications in 2021.
Walsh L, Erlanson DA, de Esch IJP, Jahnke W, Woodhead A, Wren E. Walsh L, et al. Among authors: erlanson da. J Med Chem. 2023 Jan 26;66(2):1137-1156. doi: 10.1021/acs.jmedchem.2c01827. Epub 2023 Jan 9. J Med Chem. 2023. PMID: 36622056 Review.
Fragment-to-Lead Medicinal Chemistry Publications in 2020.
de Esch IJP, Erlanson DA, Jahnke W, Johnson CN, Walsh L. de Esch IJP, et al. Among authors: erlanson da. J Med Chem. 2022 Jan 13;65(1):84-99. doi: 10.1021/acs.jmedchem.1c01803. Epub 2021 Dec 20. J Med Chem. 2022. PMID: 34928151 Free PMC article. Review.
Utilizing structure based drug design and metabolic soft spot identification to optimize the in vitro potency and in vivo pharmacokinetic properties leading to the discovery of novel reversible Bruton's tyrosine kinase inhibitors.
Hopkins BT, Bame E, Bell N, Bohnert T, Bowden-Verhoek JK, Bui M, Cancilla MT, Conlon P, Cullen P, Erlanson DA, Fan J, Fuchs-Knotts T, Hansen S, Heumann S, Jenkins TJ, Gua C, Liu Y, Liu Y, Lulla M, Marcotte D, Marx I, McDowell B, Mertsching E, Negrou E, Romanowski MJ, Scott D, Silvian L, Yang W, Zhong M. Hopkins BT, et al. Among authors: erlanson da. Bioorg Med Chem. 2021 Aug 15;44:116275. doi: 10.1016/j.bmc.2021.116275. Epub 2021 Jun 15. Bioorg Med Chem. 2021. PMID: 34314938
Targeting mutant KRAS.
Erlanson DA, Webster KR. Erlanson DA, et al. Curr Opin Chem Biol. 2021 Jun;62:101-108. doi: 10.1016/j.cbpa.2021.02.010. Epub 2021 Apr 7. Curr Opin Chem Biol. 2021. PMID: 33838397 Review.
Fragment-to-Lead Medicinal Chemistry Publications in 2019.
Jahnke W, Erlanson DA, de Esch IJP, Johnson CN, Mortenson PN, Ochi Y, Urushima T. Jahnke W, et al. Among authors: erlanson da. J Med Chem. 2020 Dec 24;63(24):15494-15507. doi: 10.1021/acs.jmedchem.0c01608. Epub 2020 Nov 23. J Med Chem. 2020. PMID: 33226222
Many small steps towards a COVID-19 drug.
Erlanson DA. Erlanson DA. Nat Commun. 2020 Oct 7;11(1):5048. doi: 10.1038/s41467-020-18710-3. Nat Commun. 2020. PMID: 33028832 Free PMC article.
Fragment-to-Lead Medicinal Chemistry Publications in 2018.
Erlanson DA, de Esch IJP, Jahnke W, Johnson CN, Mortenson PN. Erlanson DA, et al. J Med Chem. 2020 May 14;63(9):4430-4444. doi: 10.1021/acs.jmedchem.9b01581. Epub 2020 Jan 22. J Med Chem. 2020. PMID: 31913033
47 results