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Page 1
Associations of Combined Genetic and Lifestyle Risks with Incident Type 2 Diabetes in the UK Biobank.
Zhao C, Hatzikotoulas K, Balasubramanian R, Bertone-Johnson E, Cai N, Huang L, Huerta-Chagoya A, Janiczek M, Ma C, Mandla R, Paluch A, Rayner NW, Southam L, Sturgeon SR, Suzuki K, Taylor HJ, VanKim N, Yin X, Lee CH, Collins F, Spracklen CN. Zhao C, et al. Among authors: taylor hj. medRxiv [Preprint]. 2024 Dec 16:2024.12.16.24319115. doi: 10.1101/2024.12.16.24319115. medRxiv. 2024. PMID: 39763538 Free PMC article. Preprint.
Integrated clinical risk prediction of type 2 diabetes with a multifactorial polygenic risk score.
Ritchie SC, Taylor HJ, Liang Y, Manikpurage HD, Pennells L, Foguet C, Abraham G, Gibson JT, Jiang X, Liu Y, Xu Y, Kim LG, Mahajan A, McCarthy MI, Kaptoge S, Lambert SA, Wood A, Sim X, Collins FS, Denny JC, Danesh J, Butterworth AS, Di Angelantonio E, Inouye M. Ritchie SC, et al. Among authors: taylor hj. medRxiv [Preprint]. 2024 Sep 23:2024.08.22.24312440. doi: 10.1101/2024.08.22.24312440. medRxiv. 2024. PMID: 39228710 Free PMC article. Preprint.
Single-cell transcriptomic profiling of human pancreatic islets reveals genes responsive to glucose exposure over 24 h.
Grenko CM, Taylor HJ, Bonnycastle LL, Xue D, Lee BN, Weiss Z, Yan T, Swift AJ, Mansell EC, Lee A, Robertson CC, Narisu N, Erdos MR, Chen S, Collins FS, Taylor DL. Grenko CM, et al. Among authors: taylor hj. Diabetologia. 2024 Oct;67(10):2246-2259. doi: 10.1007/s00125-024-06214-4. Epub 2024 Jul 5. Diabetologia. 2024. PMID: 38967666 Free PMC article.
Genetic drivers of heterogeneity in type 2 diabetes pathophysiology.
Suzuki K, Hatzikotoulas K, Southam L, Taylor HJ, Yin X, Lorenz KM, Mandla R, Huerta-Chagoya A, Melloni GEM, Kanoni S, Rayner NW, Bocher O, Arruda AL, Sonehara K, Namba S, Lee SSK, Preuss MH, Petty LE, Schroeder P, Vanderwerff B, Kals M, Bragg F, Lin K, Guo X, Zhang W, Yao J, Kim YJ, Graff M, Takeuchi F, Nano J, Lamri A, Nakatochi M, Moon S, Scott RA, Cook JP, Lee JJ, Pan I, Taliun D, Parra EJ, Chai JF, Bielak LF, Tabara Y, Hai Y, Thorleifsson G, Grarup N, Sofer T, Wuttke M, Sarnowski C, Gieger C, Nousome D, Trompet S, Kwak SH, Long J, Sun M, Tong L, Chen WM, Nongmaithem SS, Noordam R, Lim VJY, Tam CHT, Joo YY, Chen CH, Raffield LM, Prins BP, Nicolas A, Yanek LR, Chen G, Brody JA, Kabagambe E, An P, Xiang AH, Choi HS, Cade BE, Tan J, Broadaway KA, Williamson A, Kamali Z, Cui J, Thangam M, Adair LS, Adeyemo A, Aguilar-Salinas CA, Ahluwalia TS, Anand SS, Bertoni A, Bork-Jensen J, Brandslund I, Buchanan TA, Burant CF, Butterworth AS, Canouil M, Chan JCN, Chang LC, Chee ML, Chen J, Chen SH, Chen YT, Chen Z, Chuang LM, Cushman M, Danesh J, Das SK, de Silva HJ, Dedoussis G, Dimitrov L, Doumatey AP, Du S, Duan Q, Eckardt KU, Emery LS, Evans DS, Evans MK, Fischer K, Floyd JS, Ford I… See abstract for full author list ➔ Suzuki K, et al. Among authors: taylor hj. Nature. 2024 Mar;627(8003):347-357. doi: 10.1038/s41586-024-07019-6. Epub 2024 Feb 19. Nature. 2024. PMID: 38374256 Free PMC article.
Functional interrogation of twenty type 2 diabetes-associated genes using isogenic human embryonic stem cell-derived β-like cells.
Xue D, Narisu N, Taylor DL, Zhang M, Grenko C, Taylor HJ, Yan T, Tang X, Sinha N, Zhu J, Vandana JJ, Nok Chong AC, Lee A, Mansell EC, Swift AJ, Erdos MR, Zhong A, Bonnycastle LL, Zhou T, Chen S, Collins FS. Xue D, et al. Among authors: taylor hj. Cell Metab. 2023 Nov 7;35(11):1897-1914.e11. doi: 10.1016/j.cmet.2023.09.013. Epub 2023 Oct 18. Cell Metab. 2023. PMID: 37858332 Free PMC article.
Modeling islet enhancers using deep learning identifies candidate causal variants at loci associated with T2D and glycemic traits.
Hudaiberdiev S, Taylor DL, Song W, Narisu N, Bhuiyan RM, Taylor HJ, Tang X, Yan T, Swift AJ, Bonnycastle LL, Consortium D, Chen S, Stitzel ML, Erdos MR, Ovcharenko I, Collins FS. Hudaiberdiev S, et al. Among authors: taylor hj. Proc Natl Acad Sci U S A. 2023 Aug 29;120(35):e2206612120. doi: 10.1073/pnas.2206612120. Epub 2023 Aug 21. Proc Natl Acad Sci U S A. 2023. PMID: 37603758 Free PMC article.
Single-cell transcriptomic profiling of human pancreatic islets reveals genes responsive to glucose exposure over 24 hours.
Grenko CM, Bonnycastle LL, Taylor HJ, Yan T, Swift AJ, Robertson CC, Narisu N, Erdos MR, Collins FS, Taylor DL. Grenko CM, et al. Among authors: taylor hj. bioRxiv [Preprint]. 2023 Jul 17:2023.06.06.543931. doi: 10.1101/2023.06.06.543931. bioRxiv. 2023. Update in: Diabetologia. 2024 Oct;67(10):2246-2259. doi: 10.1007/s00125-024-06214-4 PMID: 37333221 Free PMC article. Updated. Preprint.
47 results