Proamyloidogenic effects of membrane type 1 matrix metalloproteinase involve MMP-2 and BACE-1 activities, and the modulation of APP trafficking.
Paumier JM, Py NA, García-González L, Bernard A, Stephan D, Louis L, Checler F, Khrestchatisky M, Baranger K, Rivera S.
Paumier JM, et al. Among authors: bernard a.
FASEB J. 2019 Feb;33(2):2910-2927. doi: 10.1096/fj.201801076R. Epub 2018 Oct 17.
FASEB J. 2019.
PMID: 30332299
MT1-MMP-mediated processing of APP releases a soluble APP fragment, sAPP95. This process partly requires the activation of endogenous MMP-2 but is independent of beta-site APP cleaving enzyme 1 (BACE-1) or alpha-secretase activities. ...These data unveil new mechanistic in …
MT1-MMP-mediated processing of APP releases a soluble APP fragment, sAPP95. This process partly requires the activation of endogenous …