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108 results

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Page 1
A Repurposed Drug Selection Pipeline to Identify CNS-Penetrant Drug Candidates for Glioblastoma.
Ntafoulis I, Koolen SLW, van Tellingen O, den Hollander CWJ, Sabel-Goedknegt H, Dijkhuizen S, Haeck J, Reuvers TGA, de Bruijn P, van den Bosch TPP, van Dis V, Gao Z, Dirven CMF, Leenstra S, Lamfers MLM. Ntafoulis I, et al. Among authors: leenstra s. Pharmaceuticals (Basel). 2024 Dec 14;17(12):1687. doi: 10.3390/ph17121687. Pharmaceuticals (Basel). 2024. PMID: 39770529 Free PMC article.
BMP4 and Temozolomide Synergize in the Majority of Patient-Derived Glioblastoma Cultures.
Verploegh ISC, Conidi A, El Hassnaoui H, Verhoeven FAM, Korporaal AL, Ntafoulis I, van den Hout MCGN, Brouwer RWW, Lamfers MLM, van IJcken WFJ, Huylebroeck D, Leenstra S. Verploegh ISC, et al. Among authors: leenstra s. Int J Mol Sci. 2024 Sep 22;25(18):10176. doi: 10.3390/ijms251810176. Int J Mol Sci. 2024. PMID: 39337661 Free PMC article.
Cognition and health-related quality of life in long-term survivors of high-grade glioma: an interactive perspective from patient and caregiver.
Spoor JKH, Donders-Kamphuis M, Veenstra WS, van Dijk SA, Dirven CMF, Sillevis Smitt PAE, van den Bent MJ, Leenstra S, Satoer DD. Spoor JKH, et al. Among authors: leenstra s. Acta Neurochir (Wien). 2024 Apr 3;166(1):166. doi: 10.1007/s00701-024-06037-7. Acta Neurochir (Wien). 2024. PMID: 38565800 Free PMC article.
Genomic Exploration of Distinct Molecular Phenotypes Steering Temozolomide Resistance Development in Patient-Derived Glioblastoma Cells.
Fabro F, Kers TV, Feller KJ, Beerens C, Ntafoulis I, Idbaih A, Verreault M, Connor K, Biswas A, Salvucci M, Prehn JHM, Byrne AT, O'Farrell AC, Lambrechts D, Dilcan G, Lodi F, Arijs I, Kremer A, Tching Chi Yen R, Chien MP, Lamfers MLM, Leenstra S. Fabro F, et al. Among authors: leenstra s. Int J Mol Sci. 2023 Oct 27;24(21):15678. doi: 10.3390/ijms242115678. Int J Mol Sci. 2023. PMID: 37958662 Free PMC article.
Ex vivo drug sensitivity screening predicts response to temozolomide in glioblastoma patients and identifies candidate biomarkers.
Ntafoulis I, Kleijn A, Ju J, Jimenez-Cowell K, Fabro F, Klein M, Chi Yen RT, Balvers RK, Li Y, Stubbs AP, Kers TV, Kros JM, Lawler SE, Beerepoot LV, Kremer A, Idbaih A, Verreault M, Byrne AT, O'Farrell AC, Connor K, Biswas A, Salvucci M, Prehn JHM, Lambrechts D, Dilcan G, Lodi F, Arijs I, van den Bent MJ, Dirven CMF, Leenstra S; GLIOTRAIN consortium; Lamfers MLM. Ntafoulis I, et al. Among authors: leenstra s. Br J Cancer. 2023 Oct;129(8):1327-1338. doi: 10.1038/s41416-023-02402-y. Epub 2023 Aug 24. Br J Cancer. 2023. PMID: 37620410 Free PMC article.
Local delivery of hrBMP4 as an anticancer therapy in patients with recurrent glioblastoma: a first-in-human phase 1 dose escalation trial.
Bos EM, Binda E, Verploegh ISC, Wembacher E, Hoefnagel D, Balvers RK, Korporaal AL, Conidi A, Warnert EAH, Trivieri N, Visioli A, Zaccarini P, Caiola L, van Wijck R, van der Spek P, Huylebroeck D, Leenstra S, Lamfers MLM, Ram Z, Westphal M, Noske D, Legnani F, DiMeco F, Vescovi AL, Dirven CMF. Bos EM, et al. Among authors: leenstra s. Mol Cancer. 2023 Aug 10;22(1):129. doi: 10.1186/s12943-023-01835-6. Mol Cancer. 2023. PMID: 37563568 Free PMC article. Clinical Trial.
Comparative analysis of deeply phenotyped GBM cohorts of 'short-term' and 'long-term' survivors.
Biswas A, Salvucci M, Connor K, Düssmann H, Carberry S, Fichtner M, King E, Murphy B, O'Farrell AC, Cryan J, Beausang A, Heffernan J, Cremona M, Hennessy BT, Clerkin J, Sweeney KJ, MacNally S, Brett F, O'Halloran P, Bacon O, Furney S, Verreault M, Quissac E, Bielle F, Ahmed MH, Idbaih A, Leenstra S, Ntafoulis I, Fabro F, Lamfers M, Golebiewska A, Hertel F, Niclou SP, Yen RTC, Kremer A, Dilcan G, Lodi F, Arijs I, Lambrechts D, Purushothama MK, Kel A, Byrne AT, Prehn JHM. Biswas A, et al. Among authors: leenstra s. J Neurooncol. 2023 Jun;163(2):327-338. doi: 10.1007/s11060-023-04341-3. Epub 2023 May 26. J Neurooncol. 2023. PMID: 37237151 Free PMC article.
Transcriptome analysis reveals tumor microenvironment changes in glioblastoma.
Hoogstrate Y, Draaisma K, Ghisai SA, van Hijfte L, Barin N, de Heer I, Coppieters W, van den Bosch TPP, Bolleboom A, Gao Z, Vincent AJPE, Karim L, Deckers M, Taphoorn MJB, Kerkhof M, Weyerbrock A, Sanson M, Hoeben A, Lukacova S, Lombardi G, Leenstra S, Hanse M, Fleischeuer REM, Watts C, Angelopoulos N, Gorlia T, Golfinopoulos V, Bours V, van den Bent MJ, Robe PA, French PJ. Hoogstrate Y, et al. Among authors: leenstra s. Cancer Cell. 2023 Apr 10;41(4):678-692.e7. doi: 10.1016/j.ccell.2023.02.019. Epub 2023 Mar 9. Cancer Cell. 2023. PMID: 36898379 Free article.
Identification, validation and biological characterisation of novel glioblastoma tumour microenvironment subtypes: implications for precision immunotherapy.
White K, Connor K, Meylan M, Bougoüin A, Salvucci M, Bielle F, O'Farrell AC, Sweeney K, Weng L, Bergers G, Dicker P, Ashley DM, Lipp ES, Low JT, Zhao J, Wen P, Prins R, Verreault M, Idbaih A, Biswas A, Prehn JHM, Lambrechts D, Arijs I, Lodi F, Dilcan G, Lamfers M, Leenstra S, Fabro F, Ntafoulis I, Kros JM, Cryan J, Brett F, Quissac E, Beausang A, MacNally S, O'Halloran P, Clerkin J, Bacon O, Kremer A, Chi Yen RT, Varn FS, Verhaak RGW, Sautès-Fridman C, Fridman WH, Byrne AT. White K, et al. Among authors: leenstra s. Ann Oncol. 2023 Mar;34(3):300-314. doi: 10.1016/j.annonc.2022.11.008. Epub 2022 Dec 6. Ann Oncol. 2023. PMID: 36494005 Free article.
108 results