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The single-stranded DNA-binding factor SUB1/PC4 alleviates replication stress at telomeres and is a vulnerability of ALT cancer cells.
Dubois JC, Bonnell E, Filion A, Frion J, Zimmer S, Riaz Khan M, Teplitz GM, Casimir L, Méthot É, Marois I, Idrissou M, Jacques PÉ, Wellinger RJ, Maréchal A. Dubois JC, et al. Among authors: frion j. Proc Natl Acad Sci U S A. 2025 Jan 14;122(2):e2419712122. doi: 10.1073/pnas.2419712122. Epub 2025 Jan 7. Proc Natl Acad Sci U S A. 2025. PMID: 39772744
UBB pseudogene 4 encodes functional ubiquitin variants.
Dubois ML, Meller A, Samandi S, Brunelle M, Frion J, Brunet MA, Toupin A, Beaudoin MC, Jacques JF, Lévesque D, Scott MS, Lavigne P, Roucou X, Boisvert FM. Dubois ML, et al. Among authors: frion j. Nat Commun. 2020 Mar 11;11(1):1306. doi: 10.1038/s41467-020-15090-6. Nat Commun. 2020. PMID: 32161257 Free PMC article.