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The protein kinase C modulator bryostatin-1 therapeutically targets microglia to attenuate neuroinflammation and promote remyelination.
Gharibani P, Abramson E, Shanmukha S, Smith MD, Godfrey WH, Lee JJ, Hu J, Baydyuk M, Dorion MF, Deng X, Guo Y, Calle AJ, A Hwang S, Huang JK, Calabresi PA, Kornberg MD, Kim PM. Gharibani P, et al. Among authors: kornberg md. Sci Transl Med. 2025 Jan 8;17(780):eadk3434. doi: 10.1126/scitranslmed.adk3434. Epub 2025 Jan 8. Sci Transl Med. 2025. PMID: 39772770
TPPB modulates PKC activity to attenuate neuroinflammation and ameliorate experimental multiple sclerosis.
Shanmukha S, Godfrey WH, Gharibani P, Lee JJ, Guo Y, Deng X, Wender PA, Kornberg MD, Kim PM. Shanmukha S, et al. Among authors: kornberg md. bioRxiv [Preprint]. 2024 Feb 7:2024.02.02.578637. doi: 10.1101/2024.02.02.578637. bioRxiv. 2024. Update in: Front Cell Neurosci. 2024 May 22;18:1373557. doi: 10.3389/fncel.2024.1373557 PMID: 38370818 Free PMC article. Updated. Preprint.
PKC modulator bryostatin-1 therapeutically targets CNS innate immunity to attenuate neuroinflammation and promote remyelination.
Gharibani P, Abramson E, Shanmukha S, Smith MD, Godfrey WH, Lee JJ, Hu J, Baydyuk M, Dorion MF, Deng X, Guo Y, Hwang S, Huang JK, Calabresi PA, Kornberg MD, Kim PM. Gharibani P, et al. Among authors: kornberg md. bioRxiv [Preprint]. 2023 Aug 29:2023.08.28.555084. doi: 10.1101/2023.08.28.555084. bioRxiv. 2023. PMID: 37693473 Free PMC article. Preprint.
Intermittent calorie restriction alters T cell subsets and metabolic markers in people with multiple sclerosis.
Fitzgerald KC, Bhargava P, Smith MD, Vizthum D, Henry-Barron B, Kornberg MD, Cassard SD, Kapogiannis D, Sullivan P, Baer DJ, Calabresi PA, Mowry EM. Fitzgerald KC, et al. Among authors: kornberg md. EBioMedicine. 2022 Aug;82:104124. doi: 10.1016/j.ebiom.2022.104124. Epub 2022 Jul 8. EBioMedicine. 2022. PMID: 35816900 Free PMC article. Clinical Trial.
30 results