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Targeting N-Myc in neuroblastoma with selective Aurora kinase A degraders.
Tang J, Moorthy R, Hirsch LE, Demir Ö, Baker ZD, Naumann JA, Jones KFM, Grillo MJ, Haefner ES, Shi K, Levy MJ, Gupta HB, Aihara H, Harris RS, Amaro RE, Levinson NM, Harki DA. Tang J, et al. Among authors: levinson nm. Cell Chem Biol. 2025 Jan 6:S2451-9456(24)00516-6. doi: 10.1016/j.chembiol.2024.12.006. Online ahead of print. Cell Chem Biol. 2025. PMID: 39778578
Development of allosteric and selective CDK2 inhibitors for contraception with negative cooperativity to cyclin binding.
Faber EB, Sun L, Tang J, Roberts E, Ganeshkumar S, Wang N, Rasmussen D, Majumdar A, Hirsch LE, John K, Yang A, Khalid H, Hawkinson JE, Levinson NM, Chennathukuzhi V, Harki DA, Schönbrunn E, Georg GI. Faber EB, et al. Among authors: levinson nm. Nat Commun. 2023 Jun 3;14(1):3213. doi: 10.1038/s41467-023-38732-x. Nat Commun. 2023. PMID: 37270540 Free PMC article.
Allosteric coupling asymmetry mediates paradoxical activation of BRAF by type II inhibitors.
Rasmussen DM, Semonis MM, Greene JT, Muretta JM, Thompson AR, Ramos ST, Thomas DD, Pomerantz WCK, Freedman TS, Levinson NM. Rasmussen DM, et al. Among authors: levinson nm. bioRxiv [Preprint]. 2023 Nov 15:2023.04.18.536450. doi: 10.1101/2023.04.18.536450. bioRxiv. 2023. Update in: Elife. 2024 May 14;13:RP95481. doi: 10.7554/eLife.95481 PMID: 37131649 Free PMC article. Updated. Preprint.
Screening through Lead Optimization of High Affinity, Allosteric Cyclin-Dependent Kinase 2 (CDK2) Inhibitors as Male Contraceptives That Reduce Sperm Counts in Mice.
Faber EB, Wang N, John K, Sun L, Wong HL, Burban D, Francis R, Tian D, Hong KH, Yang A, Wang L, Elsaid M, Khalid H, Levinson NM, Schönbrunn E, Hawkinson JE, Georg GI. Faber EB, et al. Among authors: levinson nm. J Med Chem. 2023 Feb 9;66(3):1928-1940. doi: 10.1021/acs.jmedchem.2c01731. Epub 2023 Jan 26. J Med Chem. 2023. PMID: 36701569 Free PMC article.
Bora phosphorylation substitutes in trans for T-loop phosphorylation in Aurora A to promote mitotic entry.
Tavernier N, Thomas Y, Vigneron S, Maisonneuve P, Orlicky S, Mader P, Regmi SG, Van Hove L, Levinson NM, Gasmi-Seabrook G, Joly N, Poteau M, Velez-Aguilera G, Gavet O, Castro A, Dasso M, Lorca T, Sicheri F, Pintard L. Tavernier N, et al. Among authors: levinson nm. Nat Commun. 2021 Mar 26;12(1):1899. doi: 10.1038/s41467-021-21922-w. Nat Commun. 2021. PMID: 33771996 Free PMC article.
Allostery governs Cdk2 activation and differential recognition of CDK inhibitors.
Majumdar A, Burban DJ, Muretta JM, Thompson AR, Engel TA, Rasmussen DM, Subrahmanian MV, Veglia G, Thomas DD, Levinson NM. Majumdar A, et al. Among authors: levinson nm. Nat Chem Biol. 2021 Apr;17(4):456-464. doi: 10.1038/s41589-020-00725-y. Epub 2021 Feb 1. Nat Chem Biol. 2021. PMID: 33526892 Free PMC article.
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