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Structure guided modification of 2-chloro-5-(ethyl-phenyl-sulfamoyl)-N-[2-(2-oxo-pyrrolidin-1-yl)-phenyl]-benzamide to afford selective inhibitors of Cryptosporidium parvum N-myristoyltransferase.
Sigalapalli DK, Groustra S, Fenwick MK, Zigweid R, Hulverson MA, Owsley E, Khim M, Shibata S, Van Voorhis WC, Staker BL, Fan E. Sigalapalli DK, et al. Bioorg Med Chem Lett. 2025 Jan 6:130092. doi: 10.1016/j.bmcl.2025.130092. Online ahead of print. Bioorg Med Chem Lett. 2025. PMID: 39778753
Development of Novel Indole-3-sulfonamide-heteroaryl Hybrids as Carbonic Anhydrase Inhibitors: Design, Synthesis and in-vitro Screening.
Chinchilli KK, Singh P, Swain B, Goud NS, Sigalapalli DK, Choli A, Angeli A, Nanduri S, Yaddanapudi VM, Supuran CT, Arifuddin M. Chinchilli KK, et al. Among authors: sigalapalli dk. Anticancer Agents Med Chem. 2023;23(11):1225-1233. doi: 10.2174/1871520623666230227092821. Anticancer Agents Med Chem. 2023. PMID: 36847230
6-Shogaol Exhibits Anti-viral and Anti-inflammatory Activity in COVID-19-Associated Inflammation by Regulating NLRP3 Inflammasomes.
Kode J, Maharana J, Dar AA, Mukherjee S, Gadewal N, Sigalapalli DK, Kumar S, Panda D, Ghosh S, Keshry SS, Mamidi P, Chattopadhyay S, Pradhan T, Kailaje V, Inamdar S, Gujjarwar V. Kode J, et al. Among authors: sigalapalli dk. ACS Omega. 2023 Jan 6;8(2):2618-2628. doi: 10.1021/acsomega.2c07138. eCollection 2023 Jan 17. ACS Omega. 2023. PMID: 36687062 Free PMC article.
34 results