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Individualised oxygen delivery targeted haemodynamic therapy in high-risk surgical patients: a multicentre, randomised, double-blind, controlled, mechanistic trial.
Ackland GL, Iqbal S, Paredes LG, Toner A, Lyness C, Jenkins N, Bodger P, Karmali S, Whittle J, Reyes A, Singer M, Hamilton M, Cecconi M, Pearse RM, Mallett SV, Omar RZ; POM-O (PostOperative Morbidity-Oxygen delivery) study group. Ackland GL, et al. Among authors: whittle j. Lancet Respir Med. 2015 Jan;3(1):33-41. doi: 10.1016/S2213-2600(14)70205-X. Epub 2014 Dec 16. Lancet Respir Med. 2015. PMID: 25523407 Clinical Trial.
Spatial omics shed light on the tumour organisation of glioblastoma.
Whittle JR, Kriel J, Fatunla OE, Lu T, Moffet JJD, Spiteri M, Best SA, Freytag S. Whittle JR, et al. Semin Cell Dev Biol. 2025 Jan 8;167:1-9. doi: 10.1016/j.semcdb.2024.12.006. Online ahead of print. Semin Cell Dev Biol. 2025. PMID: 39787997 Free article. Review.
Utility of Candidate Genes From an Algorithm Designed to Predict Genetic Risk for Opioid Use Disorder.
Davis CN, Jinwala Z, Hatoum AS, Toikumo S, Agrawal A, Rentsch CT, Edenberg HJ, Baurley JW, Hartwell EE, Crist RC, Gray JC, Justice AC, Gelernter J, Kember RL, Kranzler HR; VA Million Veteran Program. Davis CN, et al. JAMA Netw Open. 2025 Jan 2;8(1):e2453913. doi: 10.1001/jamanetworkopen.2024.53913. JAMA Netw Open. 2025. PMID: 39786773 Free PMC article.
The role of vorasidenib in the treatment of isocitrate dehydrogenase-mutant glioma.
de la Fuente MI, Touat M, van den Bent MJ, Preusser M, Peters KB, Young RJ, Huang RY, Ellingson BM, Capper D, Phillips JJ, Halasz LM, Shih HA, Rudà R, Lim-Fat MJ, Blumenthal DT, Weller M, Arakawa Y, Whittle JR, Ducray F, Reardon DA, Bi WL, Minniti G, Rahman R, Hervey-Jumper S, Chang SM, Wen PY. de la Fuente MI, et al. Among authors: whittle jr. Neuro Oncol. 2024 Dec 25:noae259. doi: 10.1093/neuonc/noae259. Online ahead of print. Neuro Oncol. 2024. PMID: 39723472
High-velocity nasal insufflation versus noninvasive positive pressure ventilation for moderate acute exacerbation of chronic obstructive pulmonary disease in the emergency department: A randomized clinical trial.
Yamane DP, Jones CW, Wilkerson RG, Oliver JJ, Shahamatdar S, Loganathan A, Bolden T, Heidish R, Kelly CL, Bergeski A, Whittle JS, Dungan GC 2nd, Maisiak R, Meltzer AC. Yamane DP, et al. Among authors: whittle js. Acad Emerg Med. 2024 Dec 11. doi: 10.1111/acem.15038. Online ahead of print. Acad Emerg Med. 2024. PMID: 39663589
Tumor cell-derived spermidine promotes a protumorigenic immune microenvironment in glioblastoma via CD8+ T cell inhibition.
Kay KE, Lee J, Hong ES, Beilis J, Dayal S, Wesley ER, Mitchell S, Wang SZ, Silver DJ, Volovetz J, Johnson S, McGraw M, Grabowski MM, Lu T, Freytag L, Narayana V, Freytag S, Best SA, Whittle JR, Wang Z, Reizes O, Yu JS, Hazen SL, Brown JM, Bayik D, Lathia JD. Kay KE, et al. Among authors: whittle jr. J Clin Invest. 2024 Nov 19;135(2):e177824. doi: 10.1172/JCI177824. J Clin Invest. 2024. PMID: 39561012 Free PMC article.
Performance of Polygenic Risk Scores for Primary Open-Angle Glaucoma in Populations of African Descent.
Chang-Wolf JM, Kinzy TG, Driessen SJ, Cruz LA, Iyengar SK, Peachey NS, Aung T, Khor CC, Williams SE, Ramsay M, Olawoye O, Ashaye A, Klaver CCW, Hauser MA, Thiadens AAHJ, Cooke Bailey JN, Bonnemaijer PWM; Genetics in Glaucoma Patients of African Descent (GIGA) Study GroupGenetics of Glaucoma in People of African Descent (GGLAD) Study GroupMillion Veteran Program (MVP). Chang-Wolf JM, et al. JAMA Ophthalmol. 2025 Jan 1;143(1):7-14. doi: 10.1001/jamaophthalmol.2024.4784. JAMA Ophthalmol. 2025. PMID: 39541127
528 results