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A multi-kinase inhibitor screen identifies inhibitors preserving stem-cell-like chimeric antigen receptor T cells.
Song F, Tsahouridis O, Stucchi S, Walhart T, Mendell S, Hardy PB, Axtman M, Guduru SKR, Gilbert TSK, Graves LM, Herring LE, Savoldo B, Ma X, Woodcock M, Milner JJ, Ivanova A, Pearce KH, Xu Y, Dotti G. Song F, et al. Among authors: dotti g. Nat Immunol. 2025 Jan 8. doi: 10.1038/s41590-024-02042-1. Online ahead of print. Nat Immunol. 2025. PMID: 39779871
Chimeric antigen receptors (CARs) from bench-to-bedside.
Savoldo B, Dotti G. Savoldo B, et al. Among authors: dotti g. Immunol Lett. 2013 Sep-Oct;155(1-2):40-2. doi: 10.1016/j.imlet.2013.09.014. Epub 2013 Sep 27. Immunol Lett. 2013. PMID: 24080488 Free PMC article. Review.
Interleukin-23 engineering improves CAR T cell function in solid tumors.
Ma X, Shou P, Smith C, Chen Y, Du H, Sun C, Porterfield Kren N, Michaud D, Ahn S, Vincent B, Savoldo B, Pylayeva-Gupta Y, Zhang S, Dotti G, Xu Y. Ma X, et al. Among authors: dotti g. Nat Biotechnol. 2020 Apr;38(4):448-459. doi: 10.1038/s41587-019-0398-2. Epub 2020 Feb 3. Nat Biotechnol. 2020. PMID: 32015548 Free PMC article.
CAR-redirected natural killer T cells demonstrate superior antitumor activity to CAR-T cells through multimodal CD1d-dependent mechanisms.
Zhou X, Wang Y, Dou Z, Delfanti G, Tsahouridis O, Pellegry CM, Zingarelli M, Atassi G, Woodcock MG, Casorati G, Dellabona P, Kim WY, Guo L, Savoldo B, Tsagaratou A, Milner JJ, Metelitsa LS, Dotti G. Zhou X, et al. Among authors: dotti g. Nat Cancer. 2024 Nov;5(11):1607-1621. doi: 10.1038/s43018-024-00830-0. Epub 2024 Oct 1. Nat Cancer. 2024. PMID: 39354225
285 results