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KorB switching from DNA-sliding clamp to repressor mediates long-range gene silencing in a multi-drug resistance plasmid.
McLean TC, Balaguer-Pérez F, Chandanani J, Thomas CM, Aicart-Ramos C, Burick S, Olinares PDB, Gobbato G, Mundy JEA, Chait BT, Lawson DM, Darst SA, Campbell EA, Moreno-Herrero F, Le TBK. McLean TC, et al. Among authors: olinares pdb. Nat Microbiol. 2025 Jan 23. doi: 10.1038/s41564-024-01915-3. Online ahead of print. Nat Microbiol. 2025. PMID: 39849085
DnaB and DciA: Mechanisms of Helicase Loading and Translocation on ssDNA.
Gao N, Mazzoletti D, Peng A, Olinares PDB, Morrone C, Garavaglia A, Gouda N, Tsoy S, Mendoza A, Chowdhury A, Cerullo A, Bhavsar H, Rossi F, Rizzi M, Chait BT, Miggiano R, Jeruzalmi D. Gao N, et al. Among authors: olinares pdb. bioRxiv [Preprint]. 2024 Nov 9:2024.11.09.622779. doi: 10.1101/2024.11.09.622779. bioRxiv. 2024. PMID: 39574654 Free PMC article. Preprint.
Differential dynamics specify MeCP2 function at nucleosomes and methylated DNA.
Chua GNL, Watters JW, Olinares PDB, Begum M, Vostal LE, Luo JA, Chait BT, Liu S. Chua GNL, et al. Among authors: olinares pdb. Nat Struct Mol Biol. 2024 Nov;31(11):1789-1797. doi: 10.1038/s41594-024-01373-9. Epub 2024 Aug 20. Nat Struct Mol Biol. 2024. PMID: 39164525 Free PMC article.
Using a Function-First "Scout Fragment"-Based Approach to Develop Allosteric Covalent Inhibitors of Conformationally Dynamic Helicase Mechanoenzymes.
Ramsey JR, Shelton PMM, Heiss TK, Olinares PDB, Vostal LE, Soileau H, Grasso M, Casebeer SW, Adaniya S, Miller M, Sun S, Huggins DJ, Myers RW, Chait BT, Vinogradova EV, Kapoor TM. Ramsey JR, et al. Among authors: olinares pdb. J Am Chem Soc. 2024 Jan 10;146(1):62-67. doi: 10.1021/jacs.3c10581. Epub 2023 Dec 22. J Am Chem Soc. 2024. PMID: 38134034 Free PMC article.
Using a function-first 'scout fragment'-based approach to develop allosteric covalent inhibitors of conformationally dynamic helicase mechanoenzymes.
Ramsey JR, Shelton PMM, Heiss TK, Olinares PDB, Vostal LE, Soileau H, Grasso M, Warrington S, Adaniya S, Miller M, Sun S, Huggins DJ, Myers RW, Chait BT, Vinogradova EV, Kapoor TM. Ramsey JR, et al. Among authors: olinares pdb. bioRxiv [Preprint]. 2023 Sep 26:2023.09.25.559391. doi: 10.1101/2023.09.25.559391. bioRxiv. 2023. Update in: J Am Chem Soc. 2024 Jan 10;146(1):62-67. doi: 10.1021/jacs.3c10581 PMID: 37808863 Free PMC article. Updated. Preprint.
Structural and functional insights into the enzymatic plasticity of the SARS-CoV-2 NiRAN Domain.
Small GI, Fedorova O, Olinares PDB, Chandanani J, Banerjee A, Choi YJ, Molina H, Chait B, Darst SA, Campbell EA. Small GI, et al. Among authors: olinares pdb. bioRxiv [Preprint]. 2023 Sep 26:2023.09.25.558837. doi: 10.1101/2023.09.25.558837. bioRxiv. 2023. Update in: Mol Cell. 2023 Nov 2;83(21):3921-3930.e7. doi: 10.1016/j.molcel.2023.10.001 PMID: 37808858 Free PMC article. Updated. Preprint.
Immunodominant surface epitopes power immune evasion in the African trypanosome.
Gkeka A, Aresta-Branco F, Triller G, Vlachou EP, van Straaten M, Lilic M, Olinares PDB, Perez K, Chait BT, Blatnik R, Ruppert T, Verdi JP, Stebbins CE, Papavasiliou FN. Gkeka A, et al. Among authors: olinares pdb. Cell Rep. 2023 Mar 28;42(3):112262. doi: 10.1016/j.celrep.2023.112262. Epub 2023 Mar 20. Cell Rep. 2023. PMID: 36943866 Free article.
42 results