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APOLLOE4 Phase 3 study of oral ALZ-801/valiltramiprosate in APOE ε4/ε4 homozygotes with early Alzheimer's disease: Trial design and baseline characteristics.
Abushakra S, Porsteinsson AP, Sabbagh M, Watson D, Power A, Liang E, MacSweeney E, Boada M, Flint S, McLaine R, Kesslak JP, Hey JA, Tolar M. Abushakra S, et al. Among authors: hey ja. Alzheimers Dement (N Y). 2024 Aug 13;10(3):e12498. doi: 10.1002/trc2.12498. eCollection 2024 Jul-Sep. Alzheimers Dement (N Y). 2024. PMID: 39144121 Free PMC article.
Analysis of Cerebrospinal Fluid, Plasma β-Amyloid Biomarkers, and Cognition from a 2-Year Phase 2 Trial Evaluating Oral ALZ-801/Valiltramiprosate in APOE4 Carriers with Early Alzheimer's Disease Using Quantitative Systems Pharmacology Model.
Hey JA, Yu JY, Abushakra S, Schaefer JF, Power A, Kesslak P, Tolar M. Hey JA, et al. Drugs. 2024 Jul;84(7):825-839. doi: 10.1007/s40265-024-02068-7. Epub 2024 Jun 20. Drugs. 2024. PMID: 38902572 Free PMC article. Clinical Trial.
Effects of Oral ALZ-801/Valiltramiprosate on Plasma Biomarkers, Brain Hippocampal Volume, and Cognition: Results of 2-Year Single-Arm, Open-Label, Phase 2 Trial in APOE4 Carriers with Early Alzheimer's Disease.
Hey JA, Abushakra S, Blennow K, Reiman EM, Hort J, Prins ND, Sheardova K, Kesslak P, Shen L, Zhu X, Albayrak A, Paul J, Schaefer JF, Power A, Tolar M. Hey JA, et al. Drugs. 2024 Jul;84(7):811-823. doi: 10.1007/s40265-024-02067-8. Epub 2024 Jun 20. Drugs. 2024. PMID: 38902571 Free PMC article. Clinical Trial.
APOE ε4/ε4 homozygotes with early Alzheimer's disease show accelerated hippocampal atrophy and cortical thinning that correlates with cognitive decline.
Abushakra S, Porsteinsson AP, Sabbagh M, Bracoud L, Schaerer J, Power A, Hey JA, Scott D, Suhy J, Tolar M; Alzheimer's Disease Neuroimaging Initiative. Abushakra S, et al. Among authors: hey ja. Alzheimers Dement (N Y). 2020 Dec 4;6(1):e12117. doi: 10.1002/trc2.12117. eCollection 2020. Alzheimers Dement (N Y). 2020. PMID: 33304988 Free PMC article.
145 results