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Triple Combination of MEK, BET, and CDK Inhibitors Significantly Reduces Human Malignant Peripheral Nerve Sheath Tumors in Mouse Models.
Ortega-Bertran S, Fernández-Rodríguez J, Magallón-Lorenz M, Zhang X, Creus-Bachiller E, Diazgranados AP, Uriarte-Arrazola I, Mazuelas H, Blanco I, Valverde C, Carrió M, Villanueva A, De Raedt T, Romagosa C, Gel B, Salvador H, Ferrer M, Lázaro C, Serra E. Ortega-Bertran S, et al. Among authors: serra e. Clin Cancer Res. 2024 Dec 30. doi: 10.1158/1078-0432.CCR-24-2807. Online ahead of print. Clin Cancer Res. 2024. PMID: 39786423
A High-Throughput Screening Platform Identifies Novel Combination Treatments for Malignant Peripheral Nerve Sheath Tumors.
Fernández-Rodríguez J, Creus-Bachiller E, Zhang X, Martínez-Iniesta M, Ortega-Bertran S, Guha R, Thomas CJ, Wallace MR, Romagosa C, Salazar-Huayna L, Reilly KM, Blakely JO, Serra-Musach J, Pujana MA, Serra E, Villanueva A, Ferrer M, Lázaro C. Fernández-Rodríguez J, et al. Among authors: serra musach j, serra e. Mol Cancer Ther. 2022 Jul 5;21(7):1246-1258. doi: 10.1158/1535-7163.MCT-21-0947. Mol Cancer Ther. 2022. PMID: 35511749 Free PMC article.
Comprehensive establishment and characterization of orthoxenograft mouse models of malignant peripheral nerve sheath tumors for personalized medicine.
Castellsagué J, Gel B, Fernández-Rodríguez J, Llatjós R, Blanco I, Benavente Y, Pérez-Sidelnikova D, García-Del Muro J, Viñals JM, Vidal A, Valdés-Mas R, Terribas E, López-Doriga A, Pujana MA, Capellá G, Puente XS, Serra E, Villanueva A, Lázaro C. Castellsagué J, et al. Among authors: serra e. EMBO Mol Med. 2015 May;7(5):608-27. doi: 10.15252/emmm.201404430. EMBO Mol Med. 2015. PMID: 25810463 Free PMC article.
KIF11 and KIF15 mitotic kinesins are potential therapeutic vulnerabilities for malignant peripheral nerve sheath tumors.
Terribas E, Fernández M, Mazuelas H, Fernández-Rodríguez J, Biayna J, Blanco I, Bernal G, Ramos-Oliver I, Thomas C, Guha R, Zhang X, Gel B, Romagosa C, Ferrer M, Lázaro C, Serra E. Terribas E, et al. Among authors: serra e. Neurooncol Adv. 2020 Jan 4;2(Suppl 1):i62-i74. doi: 10.1093/noajnl/vdz061. eCollection 2020 Jul. Neurooncol Adv. 2020. PMID: 32642733 Free PMC article.
Use of patient derived orthotopic xenograft models for real-time therapy guidance in a pediatric sporadic malignant peripheral nerve sheath tumor.
Fernández-Rodríguez J, Morales La Madrid A, Gel B, Castañeda Heredia A, Salvador H, Martínez-Iniesta M, Moutinho C, Morata J, Heyn H, Blanco I, Creus-Bachiller E, Capella G, Farré L, Vidal A, Soldado F, Krauel L, Suñol M, Serra E, Villanueva A, Lázaro C. Fernández-Rodríguez J, et al. Among authors: serra e. Ther Adv Med Oncol. 2020 Jul 3;12:1758835920929579. doi: 10.1177/1758835920929579. eCollection 2020. Ther Adv Med Oncol. 2020. PMID: 32670419 Free PMC article.
Chromosomal translocations inactivating CDKN2A support a single path for malignant peripheral nerve sheath tumor initiation.
Magallón-Lorenz M, Fernández-Rodríguez J, Terribas E, Creus-Batchiller E, Romagosa C, Estival A, Perez Sidelnikova D, Salvador H, Villanueva A, Blanco I, Carrió M, Lázaro C, Serra E, Gel B. Magallón-Lorenz M, et al. Among authors: serra e. Hum Genet. 2021 Aug;140(8):1241-1252. doi: 10.1007/s00439-021-02296-x. Epub 2021 May 31. Hum Genet. 2021. PMID: 34059954
Modeling iPSC-derived human neurofibroma-like tumors in mice uncovers the heterogeneity of Schwann cells within plexiform neurofibromas.
Mazuelas H, Magallón-Lorenz M, Fernández-Rodríguez J, Uriarte-Arrazola I, Richaud-Patin Y, Terribas E, Villanueva A, Castellanos E, Blanco I, Raya Á, Chojnacki J, Heyn H, Romagosa C, Lázaro C, Gel B, Carrió M, Serra E. Mazuelas H, et al. Among authors: serra e. Cell Rep. 2022 Feb 15;38(7):110385. doi: 10.1016/j.celrep.2022.110385. Cell Rep. 2022. PMID: 35172160 Free article.
Deep genomic analysis of malignant peripheral nerve sheath tumor cell lines challenges current malignant peripheral nerve sheath tumor diagnosis.
Magallón-Lorenz M, Terribas E, Ortega-Bertran S, Creus-Bachiller E, Fernández M, Requena G, Rosas I, Mazuelas H, Uriarte-Arrazola I, Negro A, Lausová T, Castellanos E, Blanco I, DeVries G, Kawashima H, Legius E, Brems H, Mautner V, Kluwe L, Ratner N, Wallace M, Fernández-Rodriguez J, Lázaro C, Fletcher JA, Reuss D, Carrió M, Gel B, Serra E. Magallón-Lorenz M, et al. Among authors: serra e. iScience. 2023 Jan 31;26(2):106096. doi: 10.1016/j.isci.2023.106096. eCollection 2023 Feb 17. iScience. 2023. PMID: 36818284 Free PMC article.
Generation of human iPSC-derived neurofibromaspheres for in vitro and in vivo uses.
Mazuelas H, Uriarte-Arrazola I, Fernández-Rodríguez J, Magallón-Lorenz M, Villanueva A, Lázaro C, Gel B, Serra E, Carrió M. Mazuelas H, et al. Among authors: serra e. STAR Protoc. 2023 Mar 27;4(2):102198. doi: 10.1016/j.xpro.2023.102198. Online ahead of print. STAR Protoc. 2023. PMID: 36976677 Free PMC article.
435 results