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Utility of Candidate Genes From an Algorithm Designed to Predict Genetic Risk for Opioid Use Disorder.
Davis CN, Jinwala Z, Hatoum AS, Toikumo S, Agrawal A, Rentsch CT, Edenberg HJ, Baurley JW, Hartwell EE, Crist RC, Gray JC, Justice AC, Gelernter J, Kember RL, Kranzler HR; VA Million Veteran Program. Davis CN, et al. Among authors: agrawal a. JAMA Netw Open. 2025 Jan 2;8(1):e2453913. doi: 10.1001/jamanetworkopen.2024.53913. JAMA Netw Open. 2025. PMID: 39786773 Free PMC article.
Candidate Genes from an FDA-Approved Algorithm Fail to Predict Opioid Use Disorder Risk in Over 450,000 Veterans.
Davis CN, Jinwala Z, Hatoum AS, Toikumo S, Agrawal A, Rentsch CT, Edenberg HJ, Baurley JW, Hartwell EE, Crist RC, Gray JC, Justice AC, Gelernter J, Kember RL, Kranzler HR. Davis CN, et al. Among authors: agrawal a. medRxiv [Preprint]. 2024 May 16:2024.05.16.24307486. doi: 10.1101/2024.05.16.24307486. medRxiv. 2024. PMID: 38798430 Free PMC article. Preprint.
Investigation of convergent and divergent genetic influences underlying schizophrenia and alcohol use disorder.
Johnson EC, Kapoor M, Hatoum AS, Zhou H, Polimanti R, Wendt FR, Walters RK, Lai D, Kember RL, Hartz S, Meyers JL, Peterson RE, Ripke S, Bigdeli TB, Fanous AH, Pato CN, Pato MT, Goate AM, Kranzler HR, O'Donovan MC, Walters JTR, Gelernter J, Edenberg HJ, Agrawal A. Johnson EC, et al. Among authors: agrawal a. Psychol Med. 2023 Mar;53(4):1196-1204. doi: 10.1017/S003329172100266X. Epub 2021 Jul 7. Psychol Med. 2023. PMID: 34231451 Free PMC article.
The addiction risk factor: A unitary genetic vulnerability characterizes substance use disorders and their associations with common correlates.
Hatoum AS, Johnson EC, Colbert SMC, Polimanti R, Zhou H, Walters RK, Gelernter J, Edenberg HJ, Bogdan R, Agrawal A. Hatoum AS, et al. Among authors: agrawal a. Neuropsychopharmacology. 2022 Sep;47(10):1739-1745. doi: 10.1038/s41386-021-01209-w. Epub 2021 Nov 8. Neuropsychopharmacology. 2022. PMID: 34750568 Free PMC article.
Genome-wide association study in individuals of European and African ancestry and multi-trait analysis of opioid use disorder identifies 19 independent genome-wide significant risk loci.
Deak JD, Zhou H, Galimberti M, Levey DF, Wendt FR, Sanchez-Roige S, Hatoum AS, Johnson EC, Nunez YZ, Demontis D, Børglum AD, Rajagopal VM, Jennings MV, Kember RL, Justice AC, Edenberg HJ, Agrawal A, Polimanti R, Kranzler HR, Gelernter J. Deak JD, et al. Among authors: agrawal a. Mol Psychiatry. 2022 Oct;27(10):3970-3979. doi: 10.1038/s41380-022-01709-1. Epub 2022 Jul 25. Mol Psychiatry. 2022. PMID: 35879402 Free PMC article.
Generalized genetic liability to substance use disorders.
Miller AP, Bogdan R, Agrawal A, Hatoum AS. Miller AP, et al. Among authors: agrawal a. J Clin Invest. 2024 Jun 3;134(11):e172881. doi: 10.1172/JCI172881. J Clin Invest. 2024. PMID: 38828723 Free PMC article. Review.
Concerns about genetic risk testing for opioid use disorder.
Hatoum AS, Davis CN, Kember RL, Johnstone M, Oslin DW, Zinkstok JR, Burmeister M; Ethics, Position, and Public Policy Committee of the International Society of Psychiatric Genetics, Board of Directors of the International Society of Psychiatric Genetics; Agrawal A, Kranzler HR, Edenberg HJ, Gelernter J, Docherty AR, Lencz T. Hatoum AS, et al. Among authors: agrawal a. Lancet Psychiatry. 2025 Feb;12(2):94-95. doi: 10.1016/S2215-0366(24)00310-9. Epub 2024 Oct 13. Lancet Psychiatry. 2025. PMID: 39413801 No abstract available.
Genome-wide meta-analysis of problematic alcohol use in 435,563 individuals yields insights into biology and relationships with other traits.
Zhou H, Sealock JM, Sanchez-Roige S, Clarke TK, Levey DF, Cheng Z, Li B, Polimanti R, Kember RL, Smith RV, Thygesen JH, Morgan MY, Atkinson SR, Thursz MR, Nyegaard M, Mattheisen M, Børglum AD, Johnson EC, Justice AC, Palmer AA, McQuillin A, Davis LK, Edenberg HJ, Agrawal A, Kranzler HR, Gelernter J. Zhou H, et al. Among authors: agrawal a. Nat Neurosci. 2020 Jul;23(7):809-818. doi: 10.1038/s41593-020-0643-5. Epub 2020 May 25. Nat Neurosci. 2020. PMID: 32451486 Free PMC article.
4,614 results