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Structural basis for TIR domain-mediated innate immune signaling by Toll-like receptor adaptors TRIF and TRAM.
Manik MK, Pan M, Xiao L, Gu W, Kim H, Pospich S, Hedger A, Vajjhala PR, Lee MYL, Qian X, Landsberg MJ, Ve T, Nanson JD, Raunser S, Stacey KJ, Wu H, Kobe B. Manik MK, et al. Among authors: hedger a. Proc Natl Acad Sci U S A. 2025 Jan 14;122(2):e2418988122. doi: 10.1073/pnas.2418988122. Epub 2025 Jan 9. Proc Natl Acad Sci U S A. 2025. PMID: 39786929
o-Vanillin binds covalently to MAL/TIRAP Lys-210 but independently inhibits TLR2.
Rahaman MH, Thygesen SJ, Maxwell MJ, Kim H, Mudai P, Nanson JD, Jia X, Vajjhala PR, Hedger A, Vetter I, Haselhorst T, Robertson AAB, Dymock B, Ve T, Mobli M, Stacey KJ, Kobe B. Rahaman MH, et al. Among authors: hedger a. J Enzyme Inhib Med Chem. 2024 Dec;39(1):2313055. doi: 10.1080/14756366.2024.2313055. Epub 2024 Feb 28. J Enzyme Inhib Med Chem. 2024. PMID: 38416868 Free PMC article.
Discovery of Quinoxaline-Based P1-P3 Macrocyclic NS3/4A Protease Inhibitors with Potent Activity against Drug-Resistant Hepatitis C Virus Variants.
Nageswara Rao D, Zephyr J, Henes M, Chan ET, Matthew AN, Hedger AK, Conway HL, Saeed M, Newton A, Petropoulos CJ, Huang W, Kurt Yilmaz N, Schiffer CA, Ali A. Nageswara Rao D, et al. Among authors: hedger ak. J Med Chem. 2021 Aug 26;64(16):11972-11989. doi: 10.1021/acs.jmedchem.1c00554. Epub 2021 Aug 18. J Med Chem. 2021. PMID: 34405680 Free PMC article.
18 results