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Structural basis for TIR domain-mediated innate immune signaling by Toll-like receptor adaptors TRIF and TRAM.
Manik MK, Pan M, Xiao L, Gu W, Kim H, Pospich S, Hedger A, Vajjhala PR, Lee MYL, Qian X, Landsberg MJ, Ve T, Nanson JD, Raunser S, Stacey KJ, Wu H, Kobe B. Manik MK, et al. Among authors: kobe b. Proc Natl Acad Sci U S A. 2025 Jan 14;122(2):e2418988122. doi: 10.1073/pnas.2418988122. Epub 2025 Jan 9. Proc Natl Acad Sci U S A. 2025. PMID: 39786929
The JAK-STAT pathway: from structural biology to cytokine engineering.
Lv Y, Qi J, Babon JJ, Cao L, Fan G, Lang J, Zhang J, Mi P, Kobe B, Wang F. Lv Y, et al. Among authors: kobe b. Signal Transduct Target Ther. 2024 Aug 21;9(1):221. doi: 10.1038/s41392-024-01934-w. Signal Transduct Target Ther. 2024. PMID: 39169031 Free PMC article. Review.
Small molecule drug discovery targeting the JAK-STAT pathway.
Lv Y, Mi P, Babon JJ, Fan G, Qi J, Cao L, Lang J, Zhang J, Wang F, Kobe B. Lv Y, et al. Among authors: kobe b. Pharmacol Res. 2024 Jun;204:107217. doi: 10.1016/j.phrs.2024.107217. Epub 2024 May 21. Pharmacol Res. 2024. PMID: 38777110 Free article. Review.
o-Vanillin binds covalently to MAL/TIRAP Lys-210 but independently inhibits TLR2.
Rahaman MH, Thygesen SJ, Maxwell MJ, Kim H, Mudai P, Nanson JD, Jia X, Vajjhala PR, Hedger A, Vetter I, Haselhorst T, Robertson AAB, Dymock B, Ve T, Mobli M, Stacey KJ, Kobe B. Rahaman MH, et al. Among authors: kobe b. J Enzyme Inhib Med Chem. 2024 Dec;39(1):2313055. doi: 10.1080/14756366.2024.2313055. Epub 2024 Feb 28. J Enzyme Inhib Med Chem. 2024. PMID: 38416868 Free PMC article.
286 results