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Page 1
Structural basis for TIR domain-mediated innate immune signaling by Toll-like receptor adaptors TRIF and TRAM.
Manik MK, Pan M, Xiao L, Gu W, Kim H, Pospich S, Hedger A, Vajjhala PR, Lee MYL, Qian X, Landsberg MJ, Ve T, Nanson JD, Raunser S, Stacey KJ, Wu H, Kobe B. Manik MK, et al. Among authors: nanson jd. Proc Natl Acad Sci U S A. 2025 Jan 14;122(2):e2418988122. doi: 10.1073/pnas.2418988122. Epub 2025 Jan 9. Proc Natl Acad Sci U S A. 2025. PMID: 39786929
o-Vanillin binds covalently to MAL/TIRAP Lys-210 but independently inhibits TLR2.
Rahaman MH, Thygesen SJ, Maxwell MJ, Kim H, Mudai P, Nanson JD, Jia X, Vajjhala PR, Hedger A, Vetter I, Haselhorst T, Robertson AAB, Dymock B, Ve T, Mobli M, Stacey KJ, Kobe B. Rahaman MH, et al. Among authors: nanson jd. J Enzyme Inhib Med Chem. 2024 Dec;39(1):2313055. doi: 10.1080/14756366.2024.2313055. Epub 2024 Feb 28. J Enzyme Inhib Med Chem. 2024. PMID: 38416868 Free PMC article.
Cyclic ADP ribose isomers: Production, chemical structures, and immune signaling.
Manik MK, Shi Y, Li S, Zaydman MA, Damaraju N, Eastman S, Smith TG, Gu W, Masic V, Mosaiab T, Weagley JS, Hancock SJ, Vasquez E, Hartley-Tassell L, Kargios N, Maruta N, Lim BYJ, Burdett H, Landsberg MJ, Schembri MA, Prokes I, Song L, Grant M, DiAntonio A, Nanson JD, Guo M, Milbrandt J, Ve T, Kobe B. Manik MK, et al. Among authors: nanson jd. Science. 2022 Sep 30;377(6614):eadc8969. doi: 10.1126/science.adc8969. Epub 2022 Sep 30. Science. 2022. PMID: 36048923
Structural basis of SARM1 activation, substrate recognition, and inhibition by small molecules.
Shi Y, Kerry PS, Nanson JD, Bosanac T, Sasaki Y, Krauss R, Saikot FK, Adams SE, Mosaiab T, Masic V, Mao X, Rose F, Vasquez E, Furrer M, Cunnea K, Brearley A, Gu W, Luo Z, Brillault L, Landsberg MJ, DiAntonio A, Kobe B, Milbrandt J, Hughes RO, Ve T. Shi Y, et al. Among authors: nanson jd. Mol Cell. 2022 May 5;82(9):1643-1659.e10. doi: 10.1016/j.molcel.2022.03.007. Epub 2022 Mar 24. Mol Cell. 2022. PMID: 35334231 Free PMC article.
Structural Evolution of TIR-Domain Signalosomes.
Nimma S, Gu W, Maruta N, Li Y, Pan M, Saikot FK, Lim BYJ, McGuinness HY, Zaoti ZF, Li S, Desa S, Manik MK, Nanson JD, Kobe B. Nimma S, et al. Among authors: nanson jd. Front Immunol. 2021 Nov 17;12:784484. doi: 10.3389/fimmu.2021.784484. eCollection 2021. Front Immunol. 2021. PMID: 34868065 Free PMC article. Review.
23 results