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Immunopeptidomic MHC-I profiling and immunogenicity testing identifies Tcj2 as a new Chagas disease mRNA vaccine candidate.
Versteeg L, Adhikari R, Robinson G, Lee J, Wei J, Islam N, Keegan B, Russell WK, Poveda C, Villar MJ, Jones K, Bottazzi ME, Hotez P, Tijhaar E, Pollet J. Versteeg L, et al. Among authors: villar mj. PLoS Pathog. 2024 Dec 18;20(12):e1012764. doi: 10.1371/journal.ppat.1012764. eCollection 2024 Dec. PLoS Pathog. 2024. PMID: 39693359 Free PMC article.
A trivalent protein-based pan-Betacoronavirus vaccine elicits cross-neutralizing antibodies against a panel of coronavirus pseudoviruses.
Thimmiraju SR, Adhikari R, Redd JR, Villar MJ, Lee J, Liu Z, Chen YL, Sharma S, Kaur A, Uzcategui NL, Ronca SE, Chen WH, Kimata JT, Zhan B, Strych U, Bottazzi ME, Hotez PJ, Pollet J. Thimmiraju SR, et al. Among authors: villar mj. NPJ Vaccines. 2024 Jul 22;9(1):132. doi: 10.1038/s41541-024-00924-x. NPJ Vaccines. 2024. PMID: 39034332 Free PMC article.
Harnessing RNA Technology to Advance Therapeutic Vaccine Antigens against Chagas Disease.
Mancino C, Pollet J, Zinger A, Jones KM, Villar MJ, Leao AC, Adhikari R, Versteeg L, Tyagi Kundu R, Strych U, Giordano F, Hotez PJ, Bottazzi ME, Taraballi F, Poveda C. Mancino C, et al. Among authors: villar mj. ACS Appl Mater Interfaces. 2024 Apr 3;16(13):15832-15846. doi: 10.1021/acsami.3c18830. Epub 2024 Mar 22. ACS Appl Mater Interfaces. 2024. PMID: 38518375
Immunomodulatory proteins from hookworms reduce cardiac inflammation and modulate regulatory responses in a mouse model of chronic Trypanosoma cruzi infection.
Jones KM, Zhan B, Ernste KJ, Villar MJ, Bisht N, Nguyen D, Chang LY, Poveda C, Robinson GJ, Trivedi AJ, Hofferek CJ, Decker WK, Konduri V. Jones KM, et al. Among authors: villar mj. Front Parasitol. 2023;2:1244604. doi: 10.3389/fpara.2023.1244604. Epub 2023 Oct 12. Front Parasitol. 2023. PMID: 38239430 Free PMC article.
A Recombinant Protein XBB.1.5 RBD/Alum/CpG Vaccine Elicits High Neutralizing Antibody Titers against Omicron Subvariants of SARS-CoV-2.
Thimmiraju SR, Adhikari R, Villar MJ, Lee J, Liu Z, Kundu R, Chen YL, Sharma S, Ghei K, Keegan B, Versteeg L, Gillespie PM, Ciciriello A, Islam NY, Poveda C, Uzcategui N, Chen WH, Kimata JT, Zhan B, Strych U, Bottazzi ME, Hotez PJ, Pollet J. Thimmiraju SR, et al. Among authors: villar mj. Vaccines (Basel). 2023 Oct 1;11(10):1557. doi: 10.3390/vaccines11101557. Vaccines (Basel). 2023. PMID: 37896960 Free PMC article.
Heterologous mRNA-protein vaccination with Tc24 induces a robust cellular immune response against Trypanosoma cruzi, characterized by an increased level of polyfunctional CD8+ T-cells.
Poveda C, Leão AC, Mancino C, Taraballi F, Chen YL, Adhikari R, Villar MJ, Kundu R, Nguyen DM, Versteeg L, Strych U, Hotez PJ, Bottazzi ME, Pollet J, Jones KM. Poveda C, et al. Among authors: villar mj. Curr Res Immunol. 2023 Jul 20;4:100066. doi: 10.1016/j.crimmu.2023.100066. eCollection 2023. Curr Res Immunol. 2023. PMID: 37534309 Free PMC article.
Chronic pain: try new routes to more tailored treatments.
Brumovsky PR, Asla M, Villar MJ. Brumovsky PR, et al. Among authors: villar mj. Nature. 2023 May;617(7961):465. doi: 10.1038/d41586-023-01621-w. Nature. 2023. PMID: 37193813 No abstract available.
135 results