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Page 1
High-throughput drug screening identifies SMAC mimetics as enhancers of NK cell cytotoxicity in chronic myeloid leukemia.
Nygren PJ, Bouhlal JOV, Jokinen E, Forstén S, Laajala E, Dias DAA, Adnan Awad S, Ianevski A, Klievink J, Lähteenmäki H, Kuusanmäki H, Myllymäki M, Kasanen T, Saeed K, Lee DA, Flagship I, Hjorth-Hansen H, Aittokallio T, Dufva O, Mustjoki S. Nygren PJ, et al. Among authors: laajala e. Blood. 2025 Jan 10:blood.2024025286. doi: 10.1182/blood.2024025286. Online ahead of print. Blood. 2025. PMID: 39792962
Single-cell functional genomics reveals determinants of sensitivity and resistance to natural killer cells in blood cancers.
Dufva O, Gandolfi S, Huuhtanen J, Dashevsky O, Duàn H, Saeed K, Klievink J, Nygren P, Bouhlal J, Lahtela J, Näätänen A, Ghimire BR, Hannunen T, Ellonen P, Lähteenmäki H, Rumm P, Theodoropoulos J, Laajala E, Härkönen J, Pölönen P, Heinäniemi M, Hollmén M, Yamano S, Shirasaki R, Barbie DA, Roth JA, Romee R, Sheffer M, Lähdesmäki H, Lee DA, De Matos Simoes R, Kankainen M, Mitsiades CS, Mustjoki S. Dufva O, et al. Among authors: laajala e. Immunity. 2023 Dec 12;56(12):2816-2835.e13. doi: 10.1016/j.immuni.2023.11.008. Immunity. 2023. PMID: 38091953 Free article.
Single-cell analysis of immune recognition in chronic myeloid leukemia patients following tyrosine kinase inhibitor discontinuation.
Huuhtanen J, Adnan-Awad S, Theodoropoulos J, Forstén S, Warfvinge R, Dufva O, Bouhlal J, Dhapola P, Duàn H, Laajala E, Kasanen T, Klievink J, Ilander M, Jaatinen T, Olsson-Strömberg U, Hjorth-Hansen H, Burchert A, Karlsson G, Kreutzman A, Lähdesmäki H, Mustjoki S. Huuhtanen J, et al. Among authors: laajala e. Leukemia. 2024 Jan;38(1):109-125. doi: 10.1038/s41375-023-02074-w. Epub 2023 Nov 2. Leukemia. 2024. PMID: 37919606 Free PMC article.
Umbilical cord blood DNA methylation in children who later develop type 1 diabetes.
Laajala E, Kalim UU, Grönroos T, Rasool O, Halla-Aho V, Konki M, Kattelus R, Mykkänen J, Nurmio M, Vähä-Mäkilä M, Kallionpää H, Lietzén N, Ghimire BR, Laiho A, Hyöty H, Elo LL, Ilonen J, Knip M, Lund RJ, Orešič M, Veijola R, Lähdesmäki H, Toppari J, Lahesmaa R. Laajala E, et al. Diabetologia. 2022 Sep;65(9):1534-1540. doi: 10.1007/s00125-022-05726-1. Epub 2022 Jun 18. Diabetologia. 2022. PMID: 35716175 Free PMC article.
Permutation-based significance analysis reduces the type 1 error rate in bisulphite sequencing data analysis of human umbilical cord blood samples.
Laajala E, Halla-Aho V, Grönroos T, Kalim UU, Vähä-Mäkilä M, Nurmio M, Kallionpää H, Lietzén N, Mykkänen J, Rasool O, Toppari J, Orešič M, Knip M, Lund R, Lahesmaa R, Lähdesmäki H. Laajala E, et al. Epigenetics. 2022 Dec;17(12):1608-1627. doi: 10.1080/15592294.2022.2044127. Epub 2022 Mar 4. Epigenetics. 2022. PMID: 35246015 Free PMC article.
Early DNA methylation changes in children developing beta cell autoimmunity at a young age.
Starskaia I, Laajala E, Grönroos T, Härkönen T, Junttila S, Kattelus R, Kallionpää H, Laiho A, Suni V, Tillmann V, Lund R, Elo LL, Lähdesmäki H, Knip M, Kalim UU, Lahesmaa R. Starskaia I, et al. Among authors: laajala e. Diabetologia. 2022 May;65(5):844-860. doi: 10.1007/s00125-022-05657-x. Epub 2022 Feb 10. Diabetologia. 2022. PMID: 35142878 Free PMC article.
23 results