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Safety, bactericidal activity, and pharmacokinetics of the antituberculosis drug candidate BTZ-043 in South Africa (PanACEA-BTZ-043-02): an open-label, dose-expansion, randomised, controlled, phase 1b/2a trial.
Heinrich N, de Jager V, Dreisbach J, Gross-Demel P, Schultz S, Gerbach S, Kloss F, Dawson R, Narunsky K, Matt L, Wildner L, McHugh TD, Fuhr U, Aldana BH, Mouhdad C, Brake LT, Boeree MJ, Aarnoutse RE, Svensson EM, Gong X, P J Phillips P, Diacon AH, Hoelscher M; PanACEA-TB consortium. Heinrich N, et al. Among authors: wildner l. Lancet Microbe. 2024 Dec 26:100952. doi: 10.1016/j.lanmic.2024.07.015. Online ahead of print. Lancet Microbe. 2024. PMID: 39793592 Free article.
Effect of seven anti-tuberculosis treatment regimens on sputum microbiome: a retrospective analysis of the HIGHRIF study 2 and PanACEA MAMS-TB clinical trials.
Musisi E, Wyness A, Eldirdiri S, Dombay E, Mtafya B, Ntinginya NE, Heinrich N, Kibiki GS, Hoelscher M, Boeree M, Aarnoutse R, Gillespie SH, Sabiiti W; PanACEA consortium. Musisi E, et al. Lancet Microbe. 2023 Nov;4(11):e913-e922. doi: 10.1016/S2666-5247(23)00191-X. Epub 2023 Oct 10. Lancet Microbe. 2023. PMID: 37832571 Free article.
A phase IIb, open-label, randomized controlled dose ranging multi-centre trial to evaluate the safety, tolerability, pharmacokinetics and exposure-response relationship of different doses of delpazolid in combination with bedaquiline delamanid moxifloxacin in adult subjects with newly diagnosed, uncomplicated, smear-positive, drug-sensitive pulmonary tuberculosis.
Dierig A, Hoelscher M, Schultz S, Hoffmann L, Jarchow-MacDonald A, Svensson EM, Te Brake L, Aarnoutse R, Boeree M, McHugh TD, Wildner LM, Gong X, Phillips P, Minja LT, Ntinginya N, Mpagama S, Liyoyo A, Wallis RS, Sebe M, Mhimbira FA, Mbeya B, Rassool M, Geiter L, Cho YL, Heinrich N. Dierig A, et al. Among authors: wildner lm. Trials. 2023 Jun 6;24(1):382. doi: 10.1186/s13063-023-07354-5. Trials. 2023. PMID: 37280643 Free PMC article. Clinical Trial.
Thyroid hormone profile is related to prognosis in acute decompensation of cirrhosis.
Nardin G, Colombo BDS, Ronsoni MF, Silva PESE, Fayad L, Wildner LM, Bazzo ML, Dantas-Correa EB, Narciso-Schiavon JL, Schiavon LL. Nardin G, et al. Among authors: wildner lm. Arch Endocrinol Metab. 2024 Aug 13;68:e230249. doi: 10.20945/2359-4292-2023-0249. eCollection 2024. Arch Endocrinol Metab. 2024. PMID: 39420934 Free PMC article.
Systemic Inflammatory Response Syndrome in Patients Hospitalized for Acute Decompensation of Cirrhosis.
Borgonovo A, Baldin C, Maggi DC, Victor L, Bansho ETO, Piedade J, Wildner LM, Guimarães L, Bazzo ML, Rocha T, Dantas-Corrêa EB, Alcântara C, Fernandes F, Narciso-Schiavon JL, Pereira GHS, Schiavon LL. Borgonovo A, et al. Among authors: wildner lm. Can J Gastroenterol Hepatol. 2021 Apr 25;2021:5581587. doi: 10.1155/2021/5581587. eCollection 2021. Can J Gastroenterol Hepatol. 2021. PMID: 33987144 Free PMC article.
Search for Antimicrobial Activity Among Fifty-Two Natural and Synthetic Compounds Identifies Anthraquinone and Polyacetylene Classes That Inhibit Mycobacterium tuberculosis.
Pollo LAE, Martin EF, Machado VR, Cantillon D, Wildner LM, Bazzo ML, Waddell SJ, Biavatti MW, Sandjo LP. Pollo LAE, et al. Among authors: wildner lm. Front Microbiol. 2021 Jan 18;11:622629. doi: 10.3389/fmicb.2020.622629. eCollection 2020. Front Microbiol. 2021. PMID: 33537021 Free PMC article.
22 results