Chen G - Search Results

1

Development of novel GI-centric prostaglandin E₂ receptor type 4 (EP4) agonist prodrugs as treatment for ulcerative colitis and other intestinal inflammatory diseases.

Kantham S, Yu H, Cantelli CR, Chen G, Ma C, Chan JJ, Yang H, Tsai K, Lassueur K, Vallance BA, Jacobson K, Young RN. Kantham S, et al. Among authors: chen g. Bioorg Med Chem Lett. 2025 Jan 8;119:130093. doi: 10.1016/j.bmcl.2025.130093. Online ahead of print. Bioorg Med Chem Lett. 2025. PMID: 39793629

2

Design, Synthesis, and Pharmacokinetics of a Bone-Targeting Dual-Action Prodrug for the Treatment of Osteoporosis.

Xie H, Chen G, Young RN. Xie H, et al. Among authors: chen g. J Med Chem. 2017 Aug 24;60(16):7012-7028. doi: 10.1021/acs.jmedchem.6b00951. Epub 2017 Aug 10. J Med Chem. 2017. PMID: 28699744

3

Effects of treatment with a bone-targeted prostaglandin E2 receptor 4 agonist C3 (Mes-1007) in a mouse model of severe osteogenesis imperfecta.

Boraschi-Diaz I, Chen G, Polak-Nachumow J, Young RN, Rauch F. Boraschi-Diaz I, et al. Among authors: chen g. Bone. 2021 Apr;145:115867. doi: 10.1016/j.bone.2021.115867. Epub 2021 Jan 29. Bone. 2021. PMID: 33524637

4

Design, Synthesis, Pharmacokinetics, and Biodistribution of a Series of Bone-Targeting EP4 Receptor Agonist Prodrugs for Treatment of Osteoporosis and Other Bone Conditions.

Thévenin M, Chen G, Kantham S, Sun C, Glogauer M, Young RN. Thévenin M, et al. Among authors: chen g. ACS Pharmacol Transl Sci. 2021 Mar 10;4(2):908-925. doi: 10.1021/acsptsci.1c00027. eCollection 2021 Apr 9. ACS Pharmacol Transl Sci. 2021. PMID: 33860210 Free PMC article.

5

Determination of the rat in vivo pharmacokinetic profile of a bone-targeting dual-action pro-drug for treatment of osteoporosis.

Chen G, Arns S, Young RN. Chen G, et al. Bioconjug Chem. 2015 Jun 17;26(6):1095-103. doi: 10.1021/acs.bioconjchem.5b00160. Epub 2015 May 15. Bioconjug Chem. 2015. PMID: 25945831

6

Development of 2-(5,6,7-Trifluoro-1H-Indol-3-yl)-quinoline-5-carboxamide as a Potent, Selective, and Orally Available Inhibitor of Human Androgen Receptor Targeting Its Binding Function-3 for the Treatment of Castration-Resistant Prostate Cancer.

Leblanc E, Ban F, Cavga AD, Lawn S, Huang CF, Mohan S, Chang MEK, Flory MR, Ghaidi F, Lingadahalli S, Chen G, Yu IPL, Morin H, Lallous N, Gleave ME, Mohammed H, Young RN, Rennie PS, Lack NA, Cherkasov A. Leblanc E, et al. Among authors: chen g. J Med Chem. 2021 Oct 28;64(20):14968-14982. doi: 10.1021/acs.jmedchem.1c00681. Epub 2021 Oct 18. J Med Chem. 2021. PMID: 34661404

7

In vivo effects of two novel ALN-EP4a conjugate drugs on bone in the ovariectomized rat model for reversing postmenopausal bone loss.

Hu S, Liu CC, Chen G, Willett T, Young RN, Grynpas MD. Hu S, et al. Among authors: chen g. Osteoporos Int. 2016 Feb;27(2):797-808. doi: 10.1007/s00198-015-3284-x. Epub 2015 Aug 14. Osteoporos Int. 2016. PMID: 26272313

8

Novel EP4 receptor agonist-bisphosphonate conjugate drug (C1) promotes bone formation and improves vertebral mechanical properties in the ovariectomized rat model of postmenopausal bone loss.

Liu CC, Hu S, Chen G, Georgiou J, Arns S, Kumar NS, Young RN, Grynpas MD. Liu CC, et al. Among authors: chen g. J Bone Miner Res. 2015 Apr;30(4):670-80. doi: 10.1002/jbmr.2382. J Bone Miner Res. 2015. PMID: 25284325 Free article.

9

In Vivo Bone Effects of a Novel Bisphosphonate-EP4a Conjugate Drug (C3) for Reversing Osteoporotic Bone Loss in an Ovariectomized Rat Model.

Sheikh Z, Chen G, Al-Jaf F, Thévenin M, Banks K, Glogauer M, Young RN, Grynpas MD. Sheikh Z, et al. Among authors: chen g. JBMR Plus. 2019 Nov 9;3(12):e10237. doi: 10.1002/jbm4.10237. eCollection 2019 Dec. JBMR Plus. 2019. PMID: 31844825 Free PMC article.

10

Improved bone regeneration using bone anabolic drug conjugates (C3 and C6) with deproteinized bovine bone mineral as a carrier in rat mandibular defects.

Sheikh Z, Abdallah MN, Al-Jaf F, Chen G, Hamdan N, Young RN, Grynpas MD, Glogauer M. Sheikh Z, et al. Among authors: chen g. J Periodontol. 2020 Nov;91(11):1521-1531. doi: 10.1002/JPER.19-0645. Epub 2020 Apr 10. J Periodontol. 2020. PMID: 32100284

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