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Engineered Mycobacterium tuberculosis triple-kill-switch strain provides controlled tuberculosis infection in animal models.
Wang X, Su H, Wallach JB, Wagner JC, Braunecker BJ, Gardner M, Guinn KM, Howard NC, Klevorn T, Lin K, Liu YJ, Liu Y, Mugahid D, Rodgers M, Sixsmith J, Wakabayashi S, Zhu J, Zimmerman M, Dartois V, Flynn JL, Lin PL, Ehrt S, Fortune SM, Rubin EJ, Schnappinger D. Wang X, et al. Among authors: flynn jl. Nat Microbiol. 2025 Jan 10. doi: 10.1038/s41564-024-01913-5. Online ahead of print. Nat Microbiol. 2025. PMID: 39794471
A BCG kill switch strain protects against Mycobacterium tuberculosis in mice and non-human primates with improved safety and immunogenicity.
Smith AA, Su H, Wallach J, Liu Y, Maiello P, Borish HJ, Winchell C, Simonson AW, Lin PL, Rodgers M, Fillmore D, Sakal J, Lin K, Vinette V, Schnappinger D, Ehrt S, Flynn JL. Smith AA, et al. Among authors: flynn jl. Nat Microbiol. 2025 Jan 10. doi: 10.1038/s41564-024-01895-4. Online ahead of print. Nat Microbiol. 2025. PMID: 39794473
Understanding latent tuberculosis: a moving target.
Lin PL, Flynn JL. Lin PL, et al. Among authors: flynn jl. J Immunol. 2010 Jul 1;185(1):15-22. doi: 10.4049/jimmunol.0903856. J Immunol. 2010. PMID: 20562268 Free PMC article. Review.
CD8 T cells and Mycobacterium tuberculosis infection.
Lin PL, Flynn JL. Lin PL, et al. Among authors: flynn jl. Semin Immunopathol. 2015 May;37(3):239-49. doi: 10.1007/s00281-015-0490-8. Epub 2015 Apr 28. Semin Immunopathol. 2015. PMID: 25917388 Free PMC article. Review.
Heterogeneity in tuberculosis.
Cadena AM, Fortune SM, Flynn JL. Cadena AM, et al. Among authors: flynn jl. Nat Rev Immunol. 2017 Nov;17(11):691-702. doi: 10.1038/nri.2017.69. Epub 2017 Jul 24. Nat Rev Immunol. 2017. PMID: 28736436 Free PMC article. Review.
218 results