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Page 1
Ongoing chromothripsis underpins osteosarcoma genome complexity and clonal evolution.
Espejo Valle-Inclan J, De Noon S, Trevers K, Elrick H, van Belzen IAEM, Zumalave S, Sauer CM, Tanguy M, Butters T, Muyas F, Rust AG, Amary F, Tirabosco R, Giess A, Sosinsky A, Elgar G, Flanagan AM, Cortés-Ciriano I. Espejo Valle-Inclan J, et al. Among authors: van belzen iaem. Cell. 2025 Jan 9:S0092-8674(24)01418-1. doi: 10.1016/j.cell.2024.12.005. Online ahead of print. Cell. 2025. PMID: 39814020 Free article.
Complex structural variation is prevalent and highly pathogenic in pediatric solid tumors.
van Belzen IAEM, van Tuil M, Badloe S, Janse A, Verwiel ETP, Santoso M, de Vos S, Baker-Hernandez J, Kerstens HHD, Solleveld-Westerink N, Meister MT, Drost J, van den Heuvel-Eibrink MM, Merks JHM, Molenaar JJ, Peng WC, Tops BBJ, Holstege FCP, Kemmeren P, Hehir-Kwa JY. van Belzen IAEM, et al. Cell Genom. 2024 Nov 13;4(11):100675. doi: 10.1016/j.xgen.2024.100675. Epub 2024 Oct 14. Cell Genom. 2024. PMID: 39406233 Free PMC article.
Systematic discovery of gene fusions in pediatric cancer by integrating RNA-seq and WGS.
van Belzen IAEM, Cai C, van Tuil M, Badloe S, Strengman E, Janse A, Verwiel ETP, van der Leest DFM, Kester L, Molenaar JJ, Meijerink J, Drost J, Peng WC, Kerstens HHD, Tops BBJ, Holstege FCP, Kemmeren P, Hehir-Kwa JY. van Belzen IAEM, et al. BMC Cancer. 2023 Jul 3;23(1):618. doi: 10.1186/s12885-023-11054-3. BMC Cancer. 2023. PMID: 37400763 Free PMC article.
NTRK rearrangements in a subset of NF1-related malignant peripheral nerve sheath tumors as novel actionable target.
Hiemcke-Jiwa LS, Meister MT, Martin E, Dierselhuis MP, Haveman LM, Meijers RWJ, Tops BBJ, Wesseling P, van Diest PJ, van Gorp JM, Hehir-Kwa JY, van Belzen IAEM, Bonenkamp JJ, van Noesel MM, Flucke U, Kester LA. Hiemcke-Jiwa LS, et al. Among authors: van belzen iaem. Acta Neuropathol. 2023 Jan;145(1):149-152. doi: 10.1007/s00401-022-02515-3. Epub 2022 Nov 4. Acta Neuropathol. 2023. PMID: 36331594 Free PMC article. No abstract available.
Molecular Characterization Reveals Subclasses of 1q Gain in Intermediate Risk Wilms Tumors.
van Belzen IAEM, van Tuil M, Badloe S, Strengman E, Janse A, Verwiel ETP, van der Leest DFM, de Vos S, Baker-Hernandez J, Groenendijk A, de Krijger R, Kerstens HHD, Drost J, van den Heuvel-Eibrink MM, Tops BBJ, Holstege FCP, Kemmeren P, Hehir-Kwa JY. van Belzen IAEM, et al. Cancers (Basel). 2022 Oct 5;14(19):4872. doi: 10.3390/cancers14194872. Cancers (Basel). 2022. PMID: 36230794 Free PMC article.