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RSK1 is an exploitable dependency in myeloproliferative neoplasms and secondary acute myeloid leukemia.
Kong T, Laranjeira ABA, Letson CT, Yu L, Lin S, Fowles JS, Fisher DAC, Ng S, Yang W, He F, Youn M, Mark K, Jose AS, Liu J, Kim AB, Cox MJ, Fulbright MC, Jayanthan A, Los G, Rentschler SL, Ding L, Sakamoto KM, Dunn SE, Challen GA, Oh ST. Kong T, et al. Among authors: laranjeira aba. Nat Commun. 2025 Jan 16;16(1):492. doi: 10.1038/s41467-024-55643-7. Nat Commun. 2025. PMID: 39820365
RSK1 dependency in FLT3-ITD acute myeloid leukemia.
Kong T, Laranjeira ABA, Letson CT, Yu L, He F, Jayanthan A, Los G, Dunn SE, Challen GA, Oh ST. Kong T, et al. Among authors: laranjeira aba. Blood Cancer J. 2024 Nov 26;14(1):207. doi: 10.1038/s41408-024-01187-4. Blood Cancer J. 2024. PMID: 39592591 Free PMC article.
DUSP6 mediates resistance to JAK2 inhibition and drives leukemic progression.
Kong T, Laranjeira ABA, Yang K, Fisher DAC, Yu L, Poittevin De La Frégonnière L, Wang AZ, Ruzinova MB, Fowles JS, Fulbright MC, Cox MJ, Celik H, Challen GA, Huang S, Oh ST. Kong T, et al. Among authors: laranjeira aba. Nat Cancer. 2023 Jan;4(1):108-127. doi: 10.1038/s43018-022-00486-8. Epub 2022 Dec 29. Nat Cancer. 2023. PMID: 36581736 Free PMC article.
Panobinostat (LBH589) increase survival in adult xenografic model of acute lymphoblastic leukemia with t(4;11) but promotes antagonistic effects in combination with MTX and 6MP.
Moreno DA, Junior HLR, Laranjeira ABA, Cruzeiro GAV, Borges KS, Salomão KB, Ramalho FS, Yunes JA, Silva CLA, Rego EM, Scrideli CA, Tone LG. Moreno DA, et al. Among authors: laranjeira aba. Med Oncol. 2022 Sep 29;39(12):216. doi: 10.1007/s12032-022-01813-w. Med Oncol. 2022. PMID: 36175721
29 results