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Robust proteome profiling of cysteine-reactive fragments using label-free chemoproteomics.
Biggs GS, Cawood EE, Vuorinen A, McCarthy WJ, Wilders H, Riziotis IG, van der Zouwen AJ, Pettinger J, Nightingale L, Chen P, Powell AJ, House D, Boulton SJ, Skehel JM, Rittinger K, Bush JT. Biggs GS, et al. Among authors: bush jt. Nat Commun. 2025 Jan 2;16(1):73. doi: 10.1038/s41467-024-55057-5. Nat Commun. 2025. PMID: 39746958 Free PMC article.
Mapping protein binding sites by photoreactive fragment pharmacophores.
Ábrányi-Balogh P, Bajusz D, Orgován Z, Keeley AB, Petri L, Péczka N, Szalai TV, Pálfy G, Gadanecz M, Grant EK, Imre T, Takács T, Ranđelović I, Baranyi M, Marton A, Schlosser G, Ashraf QF, de Araujo ED, Karancsi T, Buday L, Tóvári J, Perczel A, Bush JT, Keserű GM. Ábrányi-Balogh P, et al. Among authors: bush jt. Commun Chem. 2024 Jul 31;7(1):168. doi: 10.1038/s42004-024-01252-w. Commun Chem. 2024. PMID: 39085342 Free PMC article.
Covalent fragment-based drug discovery for target tractability.
McCarthy WJ, van der Zouwen AJ, Bush JT, Rittinger K. McCarthy WJ, et al. Among authors: bush jt. Curr Opin Struct Biol. 2024 Jun;86:102809. doi: 10.1016/j.sbi.2024.102809. Epub 2024 Mar 29. Curr Opin Struct Biol. 2024. PMID: 38554479 Free article. Review.
Mutate and Conjugate: A Method to Enable Rapid In-Cell Target Validation.
Thomas AM, Serafini M, Grant EK, Coombs EAJ, Bluck JP, Schiedel M, McDonough MA, Reynolds JK, Lee B, Platt M, Sharlandjieva V, Biggin PC, Duarte F, Milne TA, Bush JT, Conway SJ. Thomas AM, et al. Among authors: bush jt. ACS Chem Biol. 2023 Nov 17;18(11):2405-2417. doi: 10.1021/acschembio.3c00437. Epub 2023 Oct 24. ACS Chem Biol. 2023. PMID: 37874862 Free PMC article.
31 results