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Oncogenic mutant KRAS inhibition through oxidation at cysteine 118.
Kramer-Drauberg M, Petrini E, Mira A, Patrucco E, Scardaci R, Savinelli I, Wang H, Qiao K, Carrà G, Nokin MJ, Zhou Z, Westover KD, Santamaria D, Porporato PE, Ambrogio C. Kramer-Drauberg M, et al. Among authors: westover kd. Mol Oncol. 2025 Jan 21. doi: 10.1002/1878-0261.13798. Online ahead of print. Mol Oncol. 2025. PMID: 39838816
SRC kinase drives multidrug resistance induced by KRAS-G12C inhibition.
Song X, Zhou Z, Elmezayen A, Wu R, Yu C, Gao B, Minna JD, Westover KD, Zeh HJ, Kroemer G, Heasley LE, Kang R, Tang D. Song X, et al. Among authors: westover kd. Sci Adv. 2024 Dec 13;10(50):eadq4274. doi: 10.1126/sciadv.adq4274. Epub 2024 Dec 11. Sci Adv. 2024. PMID: 39661665 Free PMC article.
Experimental variables determine the outcome of RAS-RAS interactions.
Zhou Z, Nguyen TL, Li X, Poujol C, Berlinska E, Michelina SV, Kapp JN, Plückthun A, Winslow MM, Ambrogio C, Shan Y, Santamaría D, Westover KD. Zhou Z, et al. Among authors: westover kd. J Biol Chem. 2024 Nov;300(11):107859. doi: 10.1016/j.jbc.2024.107859. Epub 2024 Oct 5. J Biol Chem. 2024. PMID: 39374781 Free PMC article.
Concerning Safety and Efficacy of Concurrent and Consolidative Durvalumab With Thoracic Radiation Therapy in PDL1-Unselected Stage III Non-Small Cell Lung Cancer: Brief Report.
Zhang Y, Iyengar P, Montalvo S, Westover KD, Rashdan S, Donthireddy K, Kim J, Dowell JE, Drapkin B, Bhalla S, Chukwuma C, Nadeem U, Ahn C, Timmerman RD, Gerber DE. Zhang Y, et al. Among authors: westover kd. Int J Radiat Oncol Biol Phys. 2025 Jan 1;121(1):68-74. doi: 10.1016/j.ijrobp.2024.07.2333. Epub 2024 Aug 13. Int J Radiat Oncol Biol Phys. 2025. PMID: 39147210 Clinical Trial.
Development of a Covalent Inhibitor of c-Jun N-Terminal Protein Kinase (JNK) 2/3 with Selectivity over JNK1.
Lu W, Liu Y, Gao Y, Geng Q, Gurbani D, Li L, Ficarro SB, Meyer CJ, Sinha D, You I, Tse J, He Z, Ji W, Che J, Kim AY, Yu T, Wen K, Anderson KC, Marto JA, Westover KD, Zhang T, Gray NS. Lu W, et al. Among authors: westover kd. J Med Chem. 2023 Mar 9;66(5):3356-3371. doi: 10.1021/acs.jmedchem.2c01834. Epub 2023 Feb 24. J Med Chem. 2023. PMID: 36826833 Free PMC article.
93 results