Borth N - Search Results

1

Characterization of large transgene integrations in Chinese hamster ovary cells using a bioengineered mammalian transposase.

Marx N, Otte AM, Leitner K, Sitepu R, Berger T, Schäpertöns V, Huber CG, Zhu Q, Nema S, Higgins JJ, Borth N. Marx N, et al. Among authors: borth n. Biotechnol Prog. 2025 Jan 23:e3524. doi: 10.1002/btpr.3524. Online ahead of print. Biotechnol Prog. 2025. PMID: 39846713

2

Corrigendum to "Manipulating gene expression levels in mammalian cell factories: An outline of synthetic molecular toolboxes to achieve multiplexed control" [New Biotechnol 79 (2024) 1-19].

Eisenhut P, Marx N, Borsi G, Papež M, Ruggeri C, Baumann M, Borth N. Eisenhut P, et al. Among authors: borth n. N Biotechnol. 2024 Dec 25;84:30-36. doi: 10.1016/j.nbt.2024.09.001. Epub 2024 Sep 26. N Biotechnol. 2024. PMID: 39332183 Free article. No abstract available.

3

Molecular biomarkers identification and applications in CHO bioprocessing.

Desmurget C, Perilleux A, Souquet J, Borth N, Douet J. Desmurget C, et al. Among authors: borth n. J Biotechnol. 2024 Sep 10;392:11-24. doi: 10.1016/j.jbiotec.2024.06.005. Epub 2024 Jun 8. J Biotechnol. 2024. PMID: 38852681 Free article. Review.

4

Combined approach of selective and accelerated cloning for microfluidic chip-based system increases clone specific productivity.

Desmurget C, Frentzel J, Strembitska A, Sobkowiak K, Perilleux A, Souquet J, Borth N, Douet J. Desmurget C, et al. Among authors: borth n. Biotechnol J. 2024 May;19(5):e2300488. doi: 10.1002/biot.202300488. Biotechnol J. 2024. PMID: 38803036

5

Manipulating gene expression levels in mammalian cell factories: An outline of synthetic molecular toolboxes to achieve multiplexed control.

Eisenhut P, Marx N, Borsi G, Papež M, Ruggeri C, Baumann M, Borth N. Eisenhut P, et al. Among authors: borth n. N Biotechnol. 2024 Mar 25;79:1-19. doi: 10.1016/j.nbt.2023.11.003. Epub 2023 Nov 30. N Biotechnol. 2024. PMID: 38040288 Free article. Review.

6

Glutamine synthetase (GS) knockout (KO) using CRISPR/Cpf1 diversely enhances selection efficiency of CHO cells expressing therapeutic antibodies.

Srila W, Baumann M, Riedl M, Rangnoi K, Borth N, Yamabhai M. Srila W, et al. Among authors: borth n. Sci Rep. 2023 Jun 28;13(1):10473. doi: 10.1038/s41598-023-37288-6. Sci Rep. 2023. PMID: 37380701 Free PMC article.

7

LncRNA analysis of mAb producing CHO clones reveals marker and engineering potential.

Novak N, Baumann M, Friss A, Cairns V, DeMaria C, Borth N. Novak N, et al. Among authors: borth n. Metab Eng. 2023 Jul;78:26-40. doi: 10.1016/j.ymben.2023.05.003. Epub 2023 May 15. Metab Eng. 2023. PMID: 37196898 Free article.

8

Nanopore Cas9-targeted sequencing enables accurate and simultaneous identification of transgene integration sites, their structure and epigenetic status in recombinant Chinese hamster ovary cells.

Leitner K, Motheramgari K, Borth N, Marx N. Leitner K, et al. Among authors: borth n. Biotechnol Bioeng. 2023 Sep;120(9):2403-2418. doi: 10.1002/bit.28382. Epub 2023 Apr 14. Biotechnol Bioeng. 2023. PMID: 36938677

9

Single-cell RNA sequencing reveals homogeneous transcriptome patterns and low variance in a suspension CHO-K1 and an adherent HEK293FT cell line in culture conditions.

Borsi G, Motheramgari K, Dhiman H, Baumann M, Sinkala E, Sauerland M, Riba J, Borth N. Borsi G, et al. Among authors: borth n. J Biotechnol. 2023 Feb 20;364:13-22. doi: 10.1016/j.jbiotec.2023.01.006. Epub 2023 Jan 26. J Biotechnol. 2023. PMID: 36708997 Free article.

10

SLAM-seq reveals early transcriptomic response mechanisms upon glutamine deprivation in Chinese hamster ovary cells.

Papež M, Jiménez Lancho V, Eisenhut P, Motheramgari K, Borth N. Papež M, et al. Among authors: borth n. Biotechnol Bioeng. 2023 Apr;120(4):970-986. doi: 10.1002/bit.28320. Epub 2023 Jan 15. Biotechnol Bioeng. 2023. PMID: 36575109

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