Brown NC - Search Results

1

Design and characterization of N2-arylaminopurines which selectively inhibit replicative DNA synthesis and replication-specific DNA polymerases: guanine derivatives active on mammalian DNA polymerase alpha and bacterial DNA polymerase III.

Wright GE, Baril EF, Brown VM, Brown NC. Wright GE, et al. Among authors: brown vm, brown nc. Nucleic Acids Res. 1982 Jul 24;10(14):4431-40. doi: 10.1093/nar/10.14.4431. Nucleic Acids Res. 1982. PMID: 6812026 Free PMC article.

2

Inhibition of DNA polymerase alpha by aphidicolin derivatives.

Arabshahi L, Brown N, Khan N, Wright G. Arabshahi L, et al. Nucleic Acids Res. 1988 Jun 10;16(11):5107-13. doi: 10.1093/nar/16.11.5107. Nucleic Acids Res. 1988. PMID: 3133639 Free PMC article.

3

Development of novel inhibitor probes of DNA polymerase III based on dGTP analogs of the HPUra type: base, nucleoside and nucleotide derivatives of N2-(3,4-dichlorobenzyl)guanine.

Butler MM, Dudycz LW, Khan NN, Wright GE, Brown NC. Butler MM, et al. Among authors: brown nc. Nucleic Acids Res. 1990 Dec 25;18(24):7381-7. doi: 10.1093/nar/18.24.7381. Nucleic Acids Res. 1990. PMID: 2259629 Free PMC article.

4

Rational design of substrate analogues targeted to selectively inhibit replication-specific DNA polymerases.

Brown NC, Dudycz LW, Wright GE. Brown NC, et al. Drugs Exp Clin Res. 1986;12(6-7):555-64. Drugs Exp Clin Res. 1986. PMID: 3091344

5

Elucidation of the mechanism of selective inhibition of mammalian DNA polymerase alpha by 2-butylanilinopurines: development and characterization of 2-(p-n-butylanilino)adenine and its deoxyribonucleotides.

Khan NN, Wright GE, Dudycz LW, Brown NC. Khan NN, et al. Among authors: brown nc. Nucleic Acids Res. 1985 Sep 11;13(17):6331-42. doi: 10.1093/nar/13.17.6331. Nucleic Acids Res. 1985. PMID: 3931053 Free PMC article.

6

Butylanilinouracil: a selective inhibitor of HeLa cell DNA synthesis and HeLa cell DNA polymerase alpha.

Wright GE, Baril EF, Brown NC. Wright GE, et al. Among authors: brown nc. Nucleic Acids Res. 1980 Jan 11;8(1):99-109. doi: 10.1093/nar/8.1.99. Nucleic Acids Res. 1980. PMID: 6153466 Free PMC article.

7

Butylphenyl dGTP: a selective and potent inhibitor of mammalian DNA polymerase alpha.

Khan NN, Wright GE, Dudycz LW, Brown NC. Khan NN, et al. Among authors: brown nc. Nucleic Acids Res. 1984 Apr 25;12(8):3695-706. doi: 10.1093/nar/12.8.3695. Nucleic Acids Res. 1984. PMID: 6728682 Free PMC article.

8

The molecular mechanism of inhibition of alpha-type DNA polymerases by N2-(butylphenyl)dGTP and 2-(butylanilino)dATP: variation in susceptibility to polymerization.

Khan NN, Wright GE, Brown NC. Khan NN, et al. Among authors: brown nc. Nucleic Acids Res. 1991 Apr 11;19(7):1627-32. doi: 10.1093/nar/19.7.1627. Nucleic Acids Res. 1991. PMID: 2027770 Free PMC article.

9

Active site directed inhibitors of replication-specific bacterial DNA polymerases.

Wright GE, Brown NC, Xu WC, Long ZY, Zhi C, Gambino JJ, Barnes MH, Butler MM. Wright GE, et al. Among authors: brown nc. Bioorg Med Chem Lett. 2005 Feb 1;15(3):729-32. doi: 10.1016/j.bmcl.2004.11.016. Bioorg Med Chem Lett. 2005. PMID: 15664846

10

Deoxyribonucleotide analogs as inhibitors and substrates of DNA polymerases.

Wright GE, Brown NC. Wright GE, et al. Among authors: brown nc. Pharmacol Ther. 1990;47(3):447-97. doi: 10.1016/0163-7258(90)90066-b. Pharmacol Ther. 1990. PMID: 2290857 Review.

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