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Page 1
Enhancement of Glutamate Uptake as Novel Antiseizure Approach: Preclinical Proof of Concept.
Kamiński K, Socała K, Abram M, Jakubiec M, Reeb KL, Temmermand R, Zagaja M, Maj M, Kolasa M, Faron-Górecka A, Andres-Mach M, Szewczyk A, Hameed MQ, Fontana ACK, Rotenberg A, Kamiński RM. Kamiński K, et al. Among authors: kaminski rm. Ann Neurol. 2024 Nov 8. doi: 10.1002/ana.27124. Online ahead of print. Ann Neurol. 2024. PMID: 39512205
Discovery and Profiling of New Multimodal Phenylglycinamide Derivatives as Potent Antiseizure and Antinociceptive Drug Candidates.
Jakubiec M, Abram M, Zagaja M, Socała K, Panic V, Latacz G, Mogilski S, Szafarz M, Szala-Rycaj J, Saunders J, West PJ, Nieoczym D, Przejczowska-Pomierny K, Szulczyk B, Krupa A, Wyska E, Wlaź P, Metcalf CS, Wilcox K, Andres-Mach M, Kamiński RM, Kamiński K. Jakubiec M, et al. Among authors: kaminski rm. ACS Chem Neurosci. 2024 Sep 4;15(17):3228-3256. doi: 10.1021/acschemneuro.4c00438. Epub 2024 Aug 21. ACS Chem Neurosci. 2024. PMID: 39166702 Free PMC article.
New epilepsy therapies in development.
Klein P, Kaminski RM, Koepp M, Löscher W. Klein P, et al. Among authors: kaminski rm. Nat Rev Drug Discov. 2024 Sep;23(9):682-708. doi: 10.1038/s41573-024-00981-w. Epub 2024 Jul 22. Nat Rev Drug Discov. 2024. PMID: 39039153 Review.
TRPV1 channel in the pathophysiology of epilepsy and its potential as a molecular target for the development of new antiseizure drug candidates.
Socała K, Jakubiec M, Abram M, Mlost J, Starowicz K, Kamiński RM, Ciepiela K, Andres-Mach M, Zagaja M, Metcalf CS, Zawadzki P, Wlaź P, Kamiński K. Socała K, et al. Among authors: kaminski rm. Prog Neurobiol. 2024 Sep;240:102634. doi: 10.1016/j.pneurobio.2024.102634. Epub 2024 Jun 2. Prog Neurobiol. 2024. PMID: 38834133 Free article. Review.
Novel Alaninamide Derivatives with Drug-like Potential for Development as Antiseizure and Antinociceptive Therapies─In Vitro and In Vivo Characterization.
Jakubiec M, Abram M, Zagaja M, Andres-Mach M, Szala-Rycaj J, Latacz G, Honkisz-Orzechowska E, Mogilski S, Kubacka M, Szafarz M, Pociecha K, Przejczowska-Pomierny K, Wyska E, Socała K, Nieoczym D, Szulczyk B, Wlaź P, Metcalf CS, Wilcox K, Kamiński RM, Kamiński K. Jakubiec M, et al. Among authors: kaminski rm. ACS Chem Neurosci. 2024 Jun 5;15(11):2198-2222. doi: 10.1021/acschemneuro.4c00013. Epub 2024 May 14. ACS Chem Neurosci. 2024. PMID: 38741575 Free PMC article.
Discovery of (R)-N-Benzyl-2-(2,5-dioxopyrrolidin-1-yl)propanamide [(R)-AS-1], a Novel Orally Bioavailable EAAT2 Modulator with Drug-like Properties and Potent Antiseizure Activity In Vivo.
Abram M, Jakubiec M, Reeb K, Cheng MH, Gedschold R, Rapacz A, Mogilski S, Socała K, Nieoczym D, Szafarz M, Latacz G, Szulczyk B, Kalinowska-Tłuścik J, Gawel K, Esguerra CV, Wyska E, Müller CE, Bahar I, Fontana ACK, Wlaź P, Kamiński RM, Kamiński K. Abram M, et al. Among authors: kaminski rm. J Med Chem. 2022 Sep 8;65(17):11703-11725. doi: 10.1021/acs.jmedchem.2c00534. Epub 2022 Aug 19. J Med Chem. 2022. PMID: 35984707 Free PMC article.
96 results