Jacobson AE - Search Results

1

Biological effects of modified colchicines. Improved preparation of 2-demethylcolchicine, 3-demethylcolchicine, and (+)-colchicine and reassignment of the position of the double bond in dehydro-7-deacetamidocolchicines.

Rösner M, Capraro HG, Jacobson AE, Atwell L, Brossi A, Iorio MA, Williams TH, Sik RH, Chignell CF. Rösner M, et al. Among authors: jacobson ae. J Med Chem. 1981 Mar;24(3):257-61. doi: 10.1021/jm00135a005. J Med Chem. 1981. PMID: 7265112

2

Biological effects of modified colchicines. 2. Evaluation of catecholic colchicines, colchifolines, colchicide, and novel N-acyl- and N-aroyldeacetylcolchicines.

Brossi A, Sharma PN, Atwell L, Jacobson AE, Iorio MA, Molinari M, Chignell CF. Brossi A, et al. Among authors: jacobson ae. J Med Chem. 1983 Oct;26(10):1365-9. doi: 10.1021/jm00364a006. J Med Chem. 1983. PMID: 6620299

3

Paradoxical effects of N-cyanoalkyl substituents upon the activities of several classes of opioids.

Jacobson AE, Rice KC, Reden J, Lupinacci L, Brossi A, Streaty RA, Klee WA. Jacobson AE, et al. J Med Chem. 1979 Mar;22(3):328-31. doi: 10.1021/jm00189a024. J Med Chem. 1979. PMID: 218015

4

Synthesis, stereochemistry, and biological activity of the 1-(1-phenyl-2-methylcyclohexyl)piperidines and the 1-(1-phenyl-4-methylcyclohexyl)piperidines. Absolute configuration of the potent trans-(-)-1-(1-phenyl-2-methylcyclohexyl)piperidine.

Iorio MA, Tomassini L, Mattson MV, George C, Jacobson AE. Iorio MA, et al. Among authors: jacobson ae. J Med Chem. 1991 Aug;34(8):2615-23. doi: 10.1021/jm00112a041. J Med Chem. 1991. PMID: 1875352

5

Synthesis and biological evaluation of 14-alkoxymorphinans. 1. Highly potent opioid agonists in the series of (-)-14-methoxy-N-methylmorphinan-6-ones.

Schmidhammer H, Aeppli L, Atwell L, Fritsch F, Jacobson AE, Nebuchla M, Sperk G. Schmidhammer H, et al. Among authors: jacobson ae. J Med Chem. 1984 Dec;27(12):1575-9. doi: 10.1021/jm00378a009. J Med Chem. 1984. PMID: 6094809

6

Deoxymorphines: role of the phenolic hydroxyl in antinociception and opiate receptor interactions.

Reden J, Reich MF, Rice KC, Jacobson AE, Brossi A, Streaty RA, Klee WA. Reden J, et al. Among authors: jacobson ae. J Med Chem. 1979 Mar;22(3):256-9. doi: 10.1021/jm00189a007. J Med Chem. 1979. PMID: 218012

7

Mammalian alkaloids. 8. Synthesis and biological effects of tetrahydropapaveroline related 1-benzyltetrahydroisoquinolines.

Brossi A, Rice KC, Mak CP, Reden J, Jacobson AE, Nimitkitpaisan Y, Skolnick P, Daly J. Brossi A, et al. Among authors: jacobson ae. J Med Chem. 1980 Jun;23(6):648-52. doi: 10.1021/jm00180a013. J Med Chem. 1980. PMID: 6248642 No abstract available.

8

Chemical and biological study of aromatic oxygenated 6-ketomorphinans.

Schmidhammer H, Jacobson AE, Brossi A. Schmidhammer H, et al. Among authors: jacobson ae. Med Res Rev. 1983 Jan-Mar;3(1):1-19. doi: 10.1002/med.2610030102. Med Res Rev. 1983. PMID: 6302413 Review. No abstract available.

9

Studies in the (+)-morphinan series. 5. Synthesis and biological properties of (+)-naloxone.

Iijima I, Minamikawa J, Jacobson AE, Brossi A, Rice KC. Iijima I, et al. Among authors: jacobson ae. J Med Chem. 1978 Apr;21(4):398-400. doi: 10.1021/jm00202a018. J Med Chem. 1978. PMID: 206698

10

Comparison of (-)-eseroline with (+)-eseroline and dihydroseco analogues in antinociceptive assays: confirmation of rubreserine structure by X-ray analysis.

Schönenberger B, Jacobson AE, Brossi A, Streaty R, Klee WA, Flippen-Anderson JL, Gilardi R. Schönenberger B, et al. Among authors: jacobson ae. J Med Chem. 1986 Nov;29(11):2268-73. doi: 10.1021/jm00161a023. J Med Chem. 1986. PMID: 3023611

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