Cook PD - Search Results

1

Drug leads from combinatorial phosphodiester libraries.

Davis PW, Vickers TA, Wilson-Lingardo L, Wyatt JR, Guinosso CJ, Sanghvi YS, DeBaets EA, Acevedo OL, Cook PD, Ecker DJ. Davis PW, et al. Among authors: cook pd. J Med Chem. 1995 Oct 27;38(22):4363-6. doi: 10.1021/jm00022a002. J Med Chem. 1995. PMID: 7473564 No abstract available.

2

Structure-activity relationships of novel 2-substituted quinazoline antibacterial agents.

Kung PP, Casper MD, Cook KL, Wilson-Lingardo L, Risen LM, Vickers TA, Ranken R, Blyn LB, Wyatt JR, Cook PD, Ecker DJ. Kung PP, et al. Among authors: cook kl, cook pd. J Med Chem. 1999 Nov 4;42(22):4705-13. doi: 10.1021/jm9903500. J Med Chem. 1999. PMID: 10579832

3

2'-O-aminopropyl ribonucleotides: a zwitterionic modification that enhances the exonuclease resistance and biological activity of antisense oligonucleotides.

Griffey RH, Monia BP, Cummins LL, Freier S, Greig MJ, Guinosso CJ, Lesnik E, Manalili SM, Mohan V, Owens S, Ross BR, Sasmor H, Wancewicz E, Weiler K, Wheeler PD, Cook PD. Griffey RH, et al. Among authors: cook pd. J Med Chem. 1996 Dec 20;39(26):5100-9. doi: 10.1021/jm950937o. J Med Chem. 1996. PMID: 8978841

4

Novel strategies towards construction of non-ionic and achiral backbones in antisense oligonucleotides.

Sanghvi YS, Vasseur JJ, Debart F, Cook PD. Sanghvi YS, et al. Among authors: cook pd. Nucleic Acids Symp Ser. 1992;(27):133-4. Nucleic Acids Symp Ser. 1992. PMID: 1289791

5

Oligodeoxynucleotides containing 2'-O-modified adenosine: synthesis and effects on stability of DNA:RNA duplexes.

Lesnik EA, Guinosso CJ, Kawasaki AM, Sasmor H, Zounes M, Cummins LL, Ecker DJ, Cook PD, Freier SM. Lesnik EA, et al. Among authors: cook pd. Biochemistry. 1993 Aug 3;32(30):7832-8. doi: 10.1021/bi00081a031. Biochemistry. 1993. PMID: 7688569

6

Evaluation of 2'-modified oligonucleotides containing 2'-deoxy gaps as antisense inhibitors of gene expression.

Monia BP, Lesnik EA, Gonzalez C, Lima WF, McGee D, Guinosso CJ, Kawasaki AM, Cook PD, Freier SM. Monia BP, et al. Among authors: cook pd. J Biol Chem. 1993 Jul 5;268(19):14514-22. J Biol Chem. 1993. PMID: 8390996 Free article.

7

Characterization of fully 2'-modified oligoribonucleotide hetero- and homoduplex hybridization and nuclease sensitivity.

Cummins LL, Owens SR, Risen LM, Lesnik EA, Freier SM, McGee D, Guinosso CJ, Cook PD. Cummins LL, et al. Among authors: cook pd. Nucleic Acids Res. 1995 Jun 11;23(11):2019-24. doi: 10.1093/nar/23.11.2019. Nucleic Acids Res. 1995. PMID: 7541132 Free PMC article.

8

Antisense oligodeoxynucleotides: synthesis, biophysical and biological evaluation of oligodeoxynucleotides containing modified pyrimidines.

Sanghvi YS, Hoke GD, Freier SM, Zounes MC, Gonzalez C, Cummins L, Sasmor H, Cook PD. Sanghvi YS, et al. Among authors: cook pd. Nucleic Acids Res. 1993 Jul 11;21(14):3197-203. doi: 10.1093/nar/21.14.3197. Nucleic Acids Res. 1993. PMID: 8393563 Free PMC article.

9

Inhibition of HIV-LTR gene expression by oligonucleotides targeted to the TAR element.

Vickers T, Baker BF, Cook PD, Zounes M, Buckheit RW Jr, Germany J, Ecker DJ. Vickers T, et al. Among authors: cook pd. Nucleic Acids Res. 1991 Jun 25;19(12):3359-68. doi: 10.1093/nar/19.12.3359. Nucleic Acids Res. 1991. PMID: 2062653 Free PMC article.

10

Discovery of novel pyridinopolyamines with potent antimicrobial activity: deconvolution of mixtures synthesized by solution-phase combinatorial chemistry.

An H, Haly BD, Cook PD. An H, et al. Among authors: cook pd. J Med Chem. 1998 Feb 26;41(5):706-16. doi: 10.1021/jm970598u. J Med Chem. 1998. PMID: 9513599

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