Grossmann M - Search Results

1

Expression of human thyrotropin in cell lines with different glycosylation patterns combined with mutagenesis of specific glycosylation sites. Characterization of a novel role for the oligosaccharides in the in vitro and in vivo bioactivity.

Grossmann M, Szkudlinski MW, Tropea JE, Bishop LA, Thotakura NR, Schofield PR, Weintraub BD. Grossmann M, et al. J Biol Chem. 1995 Dec 8;270(49):29378-85. doi: 10.1074/jbc.270.49.29378. J Biol Chem. 1995. PMID: 7493973 Free article.

2

Role of the carboxy-terminal residues of the alpha-subunit in the expression and bioactivity of human thyroid-stimulating hormone.

Grossmann M, Szkudlinski MW, Zeng H, Kraiem Z, Ji I, Tropea JE, Ji TH, Weintraub BD. Grossmann M, et al. Mol Endocrinol. 1995 Aug;9(8):948-58. doi: 10.1210/mend.9.8.7476992. Mol Endocrinol. 1995. PMID: 7476992

3

Asparagine-linked oligosaccharide structures determine clearance and organ distribution of pituitary and recombinant thyrotropin.

Szkudlinski MW, Thotakura NR, Tropea JE, Grossmann M, Weintraub BD. Szkudlinski MW, et al. Among authors: grossmann m. Endocrinology. 1995 Aug;136(8):3325-30. doi: 10.1210/endo.136.8.7628367. Endocrinology. 1995. PMID: 7628367

4

Site-directed mutagenesis of amino acids 33-44 of the common alpha-subunit reveals different structural requirements for heterodimer expression among the glycoprotein hormones and suggests that cyclic adenosine 3',5'-monophosphate production and growth promotion are potentially dissociable functions of human thyrotropin.

Grossmann M, Szkudlinski MW, Dias JA, Xia H, Wong R, Puett D, Weintraub BD. Grossmann M, et al. Mol Endocrinol. 1996 Jun;10(6):769-79. doi: 10.1210/mend.10.6.8776737. Mol Endocrinol. 1996. PMID: 8776737

5

Expression of biologically active human thyrotropin (hTSH) in a baculovirus system: effect of insect cell glycosylation on hTSH activity in vitro and in vivo.

Grossmann M, Wong R, Teh NG, Tropea JE, East-Palmer J, Weintraub BD, Szkudlinski MW. Grossmann M, et al. Endocrinology. 1997 Jan;138(1):92-100. doi: 10.1210/endo.138.1.4897. Endocrinology. 1997. PMID: 8977390

6

Substitution of the seat-belt region of the thyroid-stimulating hormone (TSH) beta-subunit with the corresponding regions of choriogonadotropin or follitropin confers luteotropic but not follitropic activity to chimeric TSH.

Grossmann M, Szkudlinski MW, Wong R, Dias JA, Ji TH, Weintraub BD. Grossmann M, et al. J Biol Chem. 1997 Jun 13;272(24):15532-40. doi: 10.1074/jbc.272.24.15532. J Biol Chem. 1997. PMID: 9182589 Free article.

7

Human thyroid-stimulating hormone (hTSH) subunit gene fusion produces hTSH with increased stability and serum half-life and compensates for mutagenesis-induced defects in subunit association.

Grossmann M, Wong R, Szkudlinski MW, Weintraub BD. Grossmann M, et al. J Biol Chem. 1997 Aug 22;272(34):21312-6. doi: 10.1074/jbc.272.34.21312. J Biol Chem. 1997. PMID: 9261143 Free article.

8

Bioengineering of human thyrotropin superactive analogs by site-directed "lysine-scanning" mutagenesis. Cooperative effects between peripheral loops.

Leitolf H, Tong KP, Grossmann M, Weintraub BD, Szkudlinski MW. Leitolf H, et al. Among authors: grossmann m. J Biol Chem. 2000 Sep 1;275(35):27457-65. doi: 10.1074/jbc.M003707200. J Biol Chem. 2000. PMID: 10859314 Free article.

9

Novel insights into the molecular mechanisms of human thyrotropin action: structural, physiological, and therapeutic implications for the glycoprotein hormone family.

Grossmann M, Weintraub BD, Szkudlinski MW. Grossmann M, et al. Endocr Rev. 1997 Aug;18(4):476-501. doi: 10.1210/edrv.18.4.0305. Endocr Rev. 1997. PMID: 9267761 Review. No abstract available.

10

A rational design strategy for protein hormone superagonists.

Grossmann M, Leitolf H, Weintraub BD, Szkudlinski MW. Grossmann M, et al. Nat Biotechnol. 1998 Sep;16(9):871-5. doi: 10.1038/nbt0998-871. Nat Biotechnol. 1998. PMID: 9743123

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